Corey H. Mjaatvedt

TL;DR: Functional biomechanical properties of periostin null skin specimens and atrioventricular valve explant experiments provided direct evidence of the role that periastin plays in regulating the viscoelastic properties of connective tissues.

TL;DR: The cardiac outlet does not derive from the paired heart-forming fields, but originates separately from a previously unrecognized source of mesoderm located anterior to the initial primitive heart tube segment, providing a new basis for explaining a variety of gene-expression patterns and cardiac defects described in both transgenic animals and human congenital heart disease.

TL;DR: Normal expression of the Cspg2 gene is required for the successful development of the endocardial cushion swellings and the embryonic heart segments that give rise to the right ventricle and conus/truncus in the outlet of the looped heart.

TL;DR: Human molecular and cardiac data suggest that the presence of three copies of gene(s) from the region is sufficient for the production of subsets of DS-CHD, and DSCAM (Down syndrome cell adhesion molecule) is proposed as a candidate gene.

TL;DR: Results highlight periostin as a mediator of matrix remodeling by cushion mesenchyme towards a mature valve structure in chick atrioventricular cushion development.