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Christine DeWilde
Researcher at Virginia Commonwealth University
Publications - 13
Citations - 1385
Christine DeWilde is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Placebo & ARDS. The author has an hindex of 9, co-authored 12 publications receiving 927 citations.
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Journal ArticleDOI
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial
Alpha A. Fowler,Jonathon D. Truwit,R. Duncan Hite,Peter E. Morris,Christine DeWilde,Anna Priday,Bernard J. Fisher,Leroy R. Thacker,Ramesh Natarajan,Donald F. Brophy,Robin Sculthorpe,Rahul Nanchal,Aamer Syed,Jamie Sturgill,Greg S. Martin,Jonathan E. Sevransky,Markos Kashiouris,Stella Hamman,Katherine Egan,Andrei Hastings,Wendy Spencer,Shawnda Tench,Omar Mehkri,James Bindas,Abhijit Duggal,Jeanette Graf,Stephanie Zellner,Lynda Yanny,Catherine McPolin,Tonya Hollrith,David W. Kramer,Charles Ojielo,Tessa Damm,Evan Cassity,Aleksandra Wieliczko,Matthew S. Halquist +35 more
TL;DR: In this preliminary study of patients with sepsis and ARDS, a 96-hour infusion of vitamin C compared with placebo did not significantly improve organ dysfunction scores or alter markers of inflammation and vascular injury.
Journal ArticleDOI
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis
Alpha A. Fowler,Aamer Syed,Shelley Knowlson,Robin Sculthorpe,Don Farthing,Christine DeWilde,Christine A. Farthing,Terri Larus,Erika J. Martin,Donald F. Brophy,Seema Gupta,Bernard J. Fisher,Ramesh Natarajan +12 more
TL;DR: Intravenous ascorbic acid infusion was safe and well tolerated in this study and may positively impact the extent of multiple organ failure and biomarkers of inflammation and endothelial injury.
Journal ArticleDOI
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial
Jonathan E. Sevransky,Richard E. Rothman,David N. Hager,Gordon R. Bernard,Samuel M. Brown,Timothy G. Buchman,Laurence W. Busse,Craig M. Coopersmith,Christine DeWilde,E. Wesley Ely,E. Wesley Ely,Lindsay M. Eyzaguirre,Alpha A. Fowler,David F. Gaieski,Michelle N. Gong,Alex Hall,Jeremiah S. Hinson,Michael H. Hooper,Gabor D. Kelen,Akram Khan,Mark Levine,Roger J. Lewis,Roger J. Lewis,Christopher J. Lindsell,Jessica S. Marlin,Anna McGlothlin,Brooks Moore,Katherine Lyn Nugent,Samuel K. Nwosu,Carmen C. Polito,Todd W. Rice,Erin P. Ricketts,Caroline C. Rudolph,Fred Sanfilippo,Kert Viele,Greg S. Martin,David W. Wright +36 more
TL;DR: In this article, a combination of vitamin C, thiamine, and hydrocortisone every 6 hours was shown to increase ventilator-and vasopressor-free days compared with placebo in patients with sepsis.
Journal ArticleDOI
Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome
Alpha A. Fowler,Christin Kim,Lawrence Lepler,Rajiv Malhotra,Orlando Debesa,Ramesh Natarajan,Bernard J. Fisher,Aamer Syed,Christine DeWilde,Anna Priday,Vigneshwar Kasirajan +10 more
TL;DR: Investigating the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS and infusing high dose vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae.
Journal ArticleDOI
Treatment of Group I Pulmonary Arterial Hypertension with Carvedilol Is Safe
Daniel C. Grinnan,Harm-Jan Bogaard,John D. Grizzard,Benjamin W. Van Tassell,Antonio Abbate,Christine DeWilde,Anna Priday,Norbert F. Voelkel +7 more
TL;DR: Carvedilol add-on treatment in patients with stable PAH and RV dysfunction led to a statistically significant improvement in RVEF and RV stroke volume, due to a reduction in RV end-systolic volume and without changes in RVend-diastolic volume.