Christine Lo

TL;DR: The results suggest that global DNA hypomethylation in breast cancer is tightly linked to the formation of repressive chromatin domains and gene silencing, thus identifying a potential epigenetic pathway for gene regulation in cancer cells.

TL;DR: This work parameterize the clone-based haplotyping problem in order to provide theoretical and empirical assessments of the impact of different parameters on haplotype assembly, and confirms the intuition that long clones help link together heterozygous variants and thus improve haplotype length.

TL;DR: The results suggest that haplotyping of large, biologically important genomic regions is feasible with current technologies, and suggest that a non-trivial distribution over advance lengths results a 1-2 order of magnitude improvement in median haplotype length.

TL;DR: A major impediment in the development of ecient full genome sequencing is the large portion of erroneous reads produced by sequencing platforms, so outlier strings potentially have great impact on the solution, and should be detected and removed.

TL;DR: It is proved that Consensus Patterns does not admit an EPTAS unless FPT=W[1], answering an open problem from [Fellows et al., STACS 2002, Combinatorica 2006].