O
Otavia L. Caballero
Researcher at Johns Hopkins University
Publications - 110
Citations - 8588
Otavia L. Caballero is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cancer & Cancer/testis antigens. The author has an hindex of 40, co-authored 106 publications receiving 8008 citations. Previous affiliations of Otavia L. Caballero include Federal University of São Paulo & Oswaldo Cruz Foundation.
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Cancer/testis antigens, gametogenesis and cancer.
TL;DR: CT antigens are being evaluated for their role in oncogenesis — recapitulation of portions of the germline gene-expression programme might contribute characteristic features to the neoplastic phenotype, including immortality, invasiveness, immune evasion, hypomethylation and metastatic capacity.
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Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids
Makiko Fliss,Henning Usadel,Otavia L. Caballero,Li Wu,Martin Buta,Scott M. Eleff,Jin Jen,David Sidransky +7 more
TL;DR: Examination of human bladder, head and neck, and lung primary tumors revealed a high frequency of mitochondrial DNA (mtDNA) mutations, indicating that the mutant mtDNA became dominant in tumor cells.
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Cancer/testis (CT) antigens: potential targets for immunotherapy.
TL;DR: Cancer vaccine trials based on CT antigens MAGE‐A3 and NY‐ESO‐1 are currently ongoing, and these antigen may also play a role in antigen‐specific adoptive T‐cell transfer and in the immunomodulation approach of cancer therapy.
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Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer
Gary C. Hon,R. David Hawkins,Otavia L. Caballero,Christine Lo,Ryan Lister,Mattia Pelizzola,Armand Valsesia,Zhen Ye,Samantha Kuan,Lee Edsall,Anamaria A. Camargo,Brian J. Stevenson,Joseph R. Ecker,Vineet Bafna,Robert L. Strausberg,Robert L. Strausberg,Andrew J. G. Simpson,Andrew J. G. Simpson,Bing Ren,Bing Ren +19 more
TL;DR: The results suggest that global DNA hypomethylation in breast cancer is tightly linked to the formation of repressive chromatin domains and gene silencing, thus identifying a potential epigenetic pathway for gene regulation in cancer cells.
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AIS is an oncogene amplified in squamous cell carcinoma
Kenji Hibi,Barry Trink,Meera Patturajan,William H. Westra,Otavia L. Caballero,David E. Hill,Edward A. Ratovitski,Jin Jen,David Sidransky +8 more
TL;DR: The results support the idea that AIS plays an oncogenic role in human cancer, and include evidence that p40/p73L, two variants lacking the N-terminal transactivation domain, in cancer.