Carolina Lucchesi

TL;DR: With this robust in vitro method for modeling human lung inflammatory disorders, it is possible to detect synergistic effects of lung endothelium and epithelium on cytokine secretion, identify new biomarkers of disease exacerbation and measure responses to anti-inflammatory compounds that inhibit cytokine-induced recruitment of circulating neutrophils under flow.

TL;DR: A neurovascular unit is created that recapitulates complex BBB functions, provides a platform for modeling inheritable neurological disorders, and advances drug screening, as well as personalized medicine.

TL;DR: A human Duodenum Intestine-Chip is created that emulates intestinal tissue architecture and functions, that are relevant for the study of drug transport, metabolism, and DDI and could enable improved in vitro to in vivo extrapolation for better predictions of human pharmacokinetics and risk of DDIs.

TL;DR: The micro-engineered Airway Lung-Chip provides a novel human-relevant platform for exploring the complex mechanisms underlying viral-induced asthma exacerbation and suggests that IL-13 may impair the hosts' ability to mount an appropriate and coordinated immune response to rhinovirus infection.

TL;DR: This work parameterize the clone-based haplotyping problem in order to provide theoretical and empirical assessments of the impact of different parameters on haplotype assembly, and confirms the intuition that long clones help link together heterozygous variants and thus improve haplotype length.