C
Christo Goridis
Researcher at École Normale Supérieure
Publications - 147
Citations - 16224
Christo Goridis is an academic researcher from École Normale Supérieure. The author has contributed to research in topics: Neural cell adhesion molecule & Antigen. The author has an hindex of 70, co-authored 147 publications receiving 15804 citations. Previous affiliations of Christo Goridis include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
TL;DR: It is shown that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain transcription factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits.
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Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.
J. Kruse,R. Mailhammer,H Wernecke,Andreas Faissner,Iris E. C. Sommer,Christo Goridis,Melitta Schachner +6 more
TL;DR: It is shown here that a carbohydrate moiety recognized by L2 and HNK-1 monoclonal antibodies, is present in mouse N-CAM and LI, which points to a previously undetected molecular diversity which may have functional implications for modulating cell adhesion during development.
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Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
TL;DR: Phox2b links early patterning events to the differentiation of defined neuronal populations in the hindbrain, suggesting a broader role for Phox1 genes in the specification of the autonomic nervous system and cranial motor nuclei than revealed by the Phox2a knock-out mice.
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Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system.
Henry Tomasiewicz,Katsuhiko Ono,Della Yee,Christian Thompson,Christo Goridis,Urs Rutishauser,Terry Magnuson +6 more
TL;DR: Analysis of the mutant in the olfactory bulb suggests that the mutant phenotype involves a defect in cell migration, possibly through specific loss of the polysialylated form of N-CAM-180, which is expressed in the migration pathway.
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The bHLH Protein NEUROGENIN 2 Is a Determination Factor for Epibranchial Placode–Derived Sensory Neurons
Carol Fode,Gérard Gradwohl,Xavier Morin,Andrée Dierich,Marianne LeMeur,Christo Goridis,François Guillemot +6 more
TL;DR: Interestingly, the homeobox gene Phox2a is activated independently of ngn2 in epibranchial placodes, suggesting that neuronal fate and neuronal subtype identity may be specified independently in cranial sensory ganglia.