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Alexandre Pattyn
Researcher at French Institute of Health and Medical Research
Publications - 39
Citations - 5090
Alexandre Pattyn is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Neurogenesis & Homeobox. The author has an hindex of 28, co-authored 38 publications receiving 4775 citations. Previous affiliations of Alexandre Pattyn include University of Montpellier & École Normale Supérieure.
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Journal ArticleDOI
The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
TL;DR: It is shown that all autonomic ganglia fail to form properly and degenerate in mice lacking the homeodomain transcription factor Phox2b, as do the three cranial sensory ganglia that are part of the autonomic reflex circuits.
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Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
TL;DR: Phox2b links early patterning events to the differentiation of defined neuronal populations in the hindbrain, suggesting a broader role for Phox1 genes in the specification of the autonomic nervous system and cranial motor nuclei than revealed by the Phox2a knock-out mice.
Journal ArticleDOI
Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways
Stéphane Dauger,Alexandre Pattyn,Frédéric Lofaso,Claude Gaultier,Christo Goridis,Jorge Gallego,Jean-François Brunet +6 more
TL;DR: It is reported that the afferent relays of visceral reflexes, differentiate under the control of the paired-like homeobox gene Phox2b: the neural crest-derived carotid body, a chemosensor organ, degenerates in homozygous mutants, as do the three epibranchial placode-derived visceral sensory ganglia (geniculate, petrosal and nodose).
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Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification.
Anna Vallstedt,Jonas Muhr,Alexandre Pattyn,Alessandra Pierani,Monica Mendelsohn,Maike Sander,Thomas M. Jessell,Johan Ericson +7 more
TL;DR: A reduction in Nkx6 activity further permits V0 neurons to be generated from progenitors that lack homeodomain proteins normally required for their generation, providing direct evidence for a model in which progenitor homeodOMain proteins direct specific cell fates by actively suppressing the expression of transcription factors that direct alternative fates.
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Phox2 genes - from patterning to connectivity.
TL;DR: What recent work on the two neuronal-type-specific transcription factors Phox2a andPhox2b has contributed to understanding of the logic in the transcriptional control of neuronal differentiation is reviewed.