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Anton F. Gietl
Researcher at University of Zurich
Publications - 48
Citations - 1390
Anton F. Gietl is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Posterior cingulate. The author has an hindex of 16, co-authored 39 publications receiving 974 citations.
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Journal ArticleDOI
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
Giovanni B. Frisoni,Marina Boccardi,Frederik Barkhof,Kaj Blennow,Kaj Blennow,Stefano F. Cappa,Stefano F. Cappa,Konstantinos Chiotis,Jean-François Démonet,Valentina Garibotto,Panteleimon Giannakopoulos,Anton F. Gietl,Oskar Hansson,Karl Herholz,Clifford R. Jack,Flavio Nobili,Flavio Nobili,Agneta Nordberg,Agneta Nordberg,Heather M. Snyder,Mara ten Kate,Andrea Varrone,Emiliano Albanese,Stefanie I. Becker,Patrick M.M. Bossuyt,Maria C. Carrillo,Chiara Cerami,Bruno Dubois,Valentina Gallo,Ezio Giacobini,Gabriel Gold,Samia Hurst,Anders Lönneborg,Karl-Olof Lövblad,Niklas Mattsson,José-Luis Molinuevo,Andreas U. Monsch,Urs Peter Mosimann,Alessandro Padovani,Agnese Picco,Agnese Picco,Corinna Porteri,Osman Ratib,Laure Saint-Aubert,Charles Scerri,Charles Scerri,Philip Scheltens,Jonathan M. Schott,Ida Sonni,Ida Sonni,Stefan J. Teipel,Stefan J. Teipel,Paolo Vineis,Pieter Jelle Visser,Pieter Jelle Visser,Yutaka Yasui,Bengt Winblad,Bengt Winblad +57 more
TL;DR: A strategic five-phase roadmap to foster the clinical validation of biomarkers in Alzheimer's disease, adapted from the approach for cancer biomarkers is developed.
Journal ArticleDOI
Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment.
J.M.G. van Bergen,Xingde Li,Xingde Li,Jun Hua,Jun Hua,SJ Schreiner,SC Steininger,F.C. Quevenco,Michael Wyss,Anton F. Gietl,Valerie Treyer,Sandra E. Leh,F Buck,Roger M. Nitsch,Klaas P. Pruessmann,P. C. M. Van Zijl,P. C. M. Van Zijl,Christoph Hock,Paul G. Unschuld +18 more
TL;DR: This study confirms earlier reports on an association between increased brain iron-burden and risk for neurocognitive dysfunction due to AD, and indicates that disease-progression is conferred by spatial colocalization of brain iron deposits with Aβ-plaques.
Journal ArticleDOI
Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.
Julian H. Birnbaum,Debora Wanner,Anton F. Gietl,Antje Saake,Thomas M. Kündig,Christoph Hock,Roger M. Nitsch,Christian Tackenberg +7 more
TL;DR: New insights into constitutional metabolic changes in neurons from subjects prone to develop Alzheimer's pathology are given and suggest that increased ROS production may have an integral role in the development of sporadic AD prior to the appearance of amyloid and tau pathology.
Journal ArticleDOI
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype
Florian Riese,Anton F. Gietl,N Zölch,Anke Henning,Ruth L. O'Gorman,Andrea M. Kälin,Sandra E. Leh,Alfred Buck,Geoffrey Warnock,Richard A.E. Edden,Roger Luechinger,Christoph Hock,Spyros Kollias,Lars Michels +13 more
TL;DR: Reductions in GABA, Glx, and NAA levels may serve as metabolic biomarkers for cognitive impairment in amnestic mild cognitive impairment and are less likely biomarker candidates for preclinical Alzheimer's disease.
Journal ArticleDOI
Clinical validity of increased cortical uptake of amyloid ligands on PET as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework.
Konstantinos Chiotis,Laure Saint-Aubert,Marina Boccardi,Anton F. Gietl,Agnese Picco,Andrea Varrone,Valentina Garibotto,Karl Herholz,Flavio Nobili,Agneta Nordberg,Agneta Nordberg,Giovanni B. Frisoni,Bengt Winblad,Clifford R. Jack +13 more
TL;DR: A literature review of the clinical validity of amyloid positron emission tomography (PET) imaging using a structured framework developed for the assessment of oncological biomarkers concludes that there is adequate evidence that the main aims of phases 1 and 2 have been achieved.