Jihye Yun

TL;DR: Studying the transcriptomes of paired colorectal cancer cell lines that differed only in the mutational status of their KRAS or BRAF genes, it is suggested that glucose deprivation can drive the acquisition of KRAS pathway mutations in human tumors.

TL;DR: It is found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C, due to increased uptake of the oxidized form of Vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter.

TL;DR: Contrary to the current view of HHT as venous disease, the findings suggest that the arterioles rather than the venules are the primary vessels affected by the loss of an Alk1 allele, and that blood vessels with reduction in AlK1 expression may harbor defects in responding to demands for vascular remodeling.

TL;DR: Three different mechanisms by which high-dose vitamin C can be selectively toxic to cancer cells are discussed, which are redox imbalance, epigenetic reprogramming and oxygen-sensing regulation.

TL;DR: Oral administration of high-fructose corn syrup is investigated in adenomatous polyposis coli mutant mice, which are predisposed to develop intestinal tumors, to support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.