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Christopher A. Penfold
Researcher at University of Cambridge
Publications - 32
Citations - 2105
Christopher A. Penfold is an academic researcher from University of Cambridge. The author has contributed to research in topics: Arabidopsis & Gene regulatory network. The author has an hindex of 15, co-authored 28 publications receiving 1739 citations. Previous affiliations of Christopher A. Penfold include Wellcome Trust/Cancer Research UK Gurdon Institute & University of Warwick.
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Journal ArticleDOI
High-Resolution Temporal Profiling of Transcripts during Arabidopsis Leaf Senescence Reveals a Distinct Chronology of Processes and Regulation
Emily Breeze,Elizabeth Harrison,Stuart McHattie,Linda Karen Hughes,Richard Hickman,Claire Hill,Steven J. Kiddle,Youn-Sung Kim,Christopher A. Penfold,Dafyd J. Jenkins,Cunjin Zhang,Karl Morris,Carol E. Jenner,Stephen D. Jackson,Brian Thomas,Alex Tabrett,Roxane Legaie,Jonathan D. Moore,David L. Wild,Sascha Ott,David A. Rand,Jim Beynon,Katherine J. Denby,Andrew Mead,Vicky Buchanan-Wollaston +24 more
TL;DR: Analysis of motif enrichment, as well as comparison of transcription factor families showing altered expression over the time course, identify clear groups of TFs active at different stages of leaf development and senescence, which will underpin the development of network models to elucidate the process of Senescence.
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Arabidopsis Defense against Botrytis cinerea: Chronology and Regulation Deciphered by High-Resolution Temporal Transcriptomic Analysis
Oliver P. Windram,Priyadharshini Madhou,Stuart McHattie,Claire Hill,Richard Hickman,Emma J. Cooke,Dafyd J. Jenkins,Christopher A. Penfold,Laura Baxter,Emily Breeze,Steven J. Kiddle,Johanna Rhodes,Susanna Atwell,Daniel J. Kliebenstein,Youn-Sung Kim,Oliver Stegle,Karsten M. Borgwardt,Karsten M. Borgwardt,Cunjin Zhang,Alex Tabrett,Roxane Legaie,Jonathan D. Moore,Bärbel Finkenstädt,David L. Wild,Andrew Mead,David A. Rand,Jim Beynon,Sascha Ott,Vicky Buchanan-Wollaston,Katherine J. Denby +29 more
TL;DR: In this article, a high-resolution time series of gene expression profiles from a single Arabidopsis thaliana leaf during infection by the necrotrophic fungal pathogen Botrytis cinerea was generated.
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How to infer gene networks from expression profiles, revisited
TL;DR: For smaller systems, DBNs are competitive with the non-parametric approaches with respect to computational time and accuracy, and both of these approaches appear to be more accurate than Granger causality-based methods and those using simple ODEs models.
Journal ArticleDOI
A local regulatory network around three NAC transcription factors in stress responses and senescence in Arabidopsis leaves
Richard Hickman,Claire Hill,Christopher A. Penfold,Emily Breeze,Laura Bowden,Jonathan D. Moore,Peijun Zhang,Alison C. Jackson,Emma J. Cooke,Findlay Bewicke-Copley,Andrew Mead,Jim Beynon,David L. Wild,Katherine J. Denby,Sascha Ott,Vicky Buchanan-Wollaston +15 more
TL;DR: Yeast 1-hybrid analysis is shown to be a valuable tool that can distinguish clades of binding proteins and be used to test and quantify protein binding to predicted promoter motifs.
Journal ArticleDOI
Transcriptional Dynamics Driving MAMP-Triggered Immunity and Pathogen Effector-Mediated Immunosuppression in Arabidopsis Leaves Following Infection with Pseudomonas syringae pv tomato DC3000
Laura Ann Lewis,Krzysztof Polanski,Marta de Torres-Zabala,Siddharth Jayaraman,Laura Bowden,Jonathan D. Moore,Christopher A. Penfold,Dafyd J. Jenkins,Claire Hill,Laura Baxter,Satish Kulasekaran,William Truman,George R. Littlejohn,Justyna Prusinska,Andrew Mead,Jens Steinbrenner,Richard Hickman,David A. Rand,David L. Wild,Sascha Ott,Vicky Buchanan-Wollaston,Nicholas Smirnoff,Jim Beynon,Katherine J. Denby,Murray Grant +24 more
TL;DR: High-resolution microarray analysis of Pseudomonas syringae-inoculated Arabidopsis leaves reveals transcriptional dynamics underpinning basal defense and effector modulation leading to disease development, and establishes causal links between the activities of pathogen effectors and suppression of MTI.