C
Christopher E. Henderson
Researcher at Columbia University
Publications - 91
Citations - 13508
Christopher E. Henderson is an academic researcher from Columbia University. The author has contributed to research in topics: Neurotrophic factors & Motor neuron. The author has an hindex of 48, co-authored 91 publications receiving 12895 citations. Previous affiliations of Christopher E. Henderson include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
Christopher E. Henderson,Heidi S. Phillips,Richard A. Pollock,Alun M. Davies,Corinne Lemeulle,Mark Armanini,Lora C. Simpson,Barbara Moffet,Richard Vandlen,Vassilis E. Koliatsos,Arnon Rosenthal +10 more
TL;DR: Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture and to be a good candidate for treatment of motoneuron disease.
Journal ArticleDOI
Characterization of a multicomponent receptor for GDNF
James J.S. Treanor,Laurie J. Goodman,Frederic J. de Sauvage,Donna M. Stone,Kristian Todd Poulsen,Claus D. Beck,Christa L. Gray,Mark Armanini,Richard A. Pollock,Franz Hefti,Heidi S. Phillips,Audry Goddard,Mark W. Moore,Anna Buj-Bello,Alun M. Davies,Naoya Asai,Masahide Takahashi,Richard Vandlen,Christopher E. Henderson,Arnon Rosenthal +19 more
TL;DR: It is demonstrated that physiological responses to GDNF require the presence of a novel glycosyl-phosphatidylinositol (GPI)-linked protein (designated GDNFR-α) that is expressed on GDNF-responsive cells and binds GDNF with a high affinity, which supports the hypothesis that GDNF uses a multi-subunit receptor system in which GDN FR-α and Ret function as the ligand-binding and signalling components.
Journal ArticleDOI
Neurotrophins promote motor neuron survival and are present in embryonic limb bud
Christopher E. Henderson,William Camu,Clément Mettling,Annie Gouin,Kristian Todd Poulsen,Mona Karihaloo,Janette Ruilamas,Tony Evans,Stephen B. McMahon,Mark Armanini,Lucy R. Berkemeier,Heidi S. Phillips,Arnon Rosenthal +12 more
TL;DR: It is shown that picomolar concentrations of three neurotrophins, brain-derived neurotrophic factor, neurotroph in-3 and neurotrophin-5, can prevent the death of cultured embryonic rat spinal motor neurons and may be physiological motor neuron growth factors.
Journal ArticleDOI
Neuronal Cell Death
TL;DR: In a short review such as this, it is not possible to establish precedence for all ideas or mechanisms, many of which originate from (or are still confined to) studies outside the nervous system, so wherever possible, the interested reader is illustrated by citing recent articles involving neurons.
Journal ArticleDOI
Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin
Jeffrey Milbrandt,Frederic J. de Sauvage,Timothy J. Fahrner,Robert H. Baloh,Melanie L. Leitner,Malú G. Tansey,Patricia A. Lampe,Robert O. Heuckeroth,Paul T. Kotzbauer,Kelli S. Simburger,Judith P. Golden,Jamie A. Davies,Richard Vejsada,Ann C. Kato,Mary Hynes,Daniel Eric Sherman,Merry Nishimura,Li-Chong Wang,Richard Vandlen,Barbara Moffat,Robert D. Klein,Kristian Todd Poulsen,Christa L. Gray,Alain Garces,Christopher E. Henderson,Heidi S. Phillips,Eugene M. Johnson +26 more
TL;DR: A novel neurotrophic factor named Persephin has been identified using degenerate PCR and, like GDNF and NTN, promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo.