M
Mark Armanini
Researcher at Genentech
Publications - 44
Citations - 17570
Mark Armanini is an academic researcher from Genentech. The author has contributed to research in topics: Neurotrophic factors & Glial cell line-derived neurotrophic factor. The author has an hindex of 35, co-authored 44 publications receiving 17137 citations.
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Journal ArticleDOI
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
TL;DR: It is demonstrated that inhibition of the action of an angiogenic factor spontaneously produced by tumour cells may suppress tumour growth in vivo.
Journal ArticleDOI
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Asa Abeliovich,Yvonne Schmitz,Isabel Fariñas,DL Choi-Lundberg,Wei Hsien Ho,Pablo E. Castillo,Natasha Shinsky,José Manuel García Verdugo,Mark Armanini,Anne M. Ryan,Mary Hynes,Heidi S. Phillips,David Sulzer,Arnon Rosenthal +13 more
TL;DR: The hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission is supported.
Journal ArticleDOI
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
Christopher E. Henderson,Heidi S. Phillips,Richard A. Pollock,Alun M. Davies,Corinne Lemeulle,Mark Armanini,Lora C. Simpson,Barbara Moffet,Richard Vandlen,Vassilis E. Koliatsos,Arnon Rosenthal +10 more
TL;DR: Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture and to be a good candidate for treatment of motoneuron disease.
Journal ArticleDOI
Renal and neuronal abnormalities in mice lacking GDNF.
Mark W. Moore,Robert D. Klein,Isabel Fariñas,Hansjorg Sauer,Mark Armanini,Heidi S. Phillips,Louis F. Reichardt,Anne M. Ryan,Karen Carver-Moore,Arnon Rosenthal +9 more
TL;DR: It is shown that at postnatal day 0 (P0), GDNF-deficient mice have deficits in dorsal root ganglion, sympathetic and nodose neurons, but not in hindbrain noradrenergic or midbrain dopaminergic neurons, and GDNF is important for the development and/or survival of enteric, sympathetic, and sensory neurons and the renal system, but is not essential for catecholaminergic neuron in the central nervous system (CNS).
Journal ArticleDOI
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
Donna M. Stone,Mary Hynes,Mark Armanini,Todd A. Swanson,Qimin Gu,Ronald L. Johnson,Matthew P. Scott,Diane Pennica,Audrey Goddard,Heidi S. Phillips,Markus Noll,Joan E. Hooper,Frederic J. de Sauvage,Arnon Rosenthal +13 more
TL;DR: It is shown that Re can form a physical complex with a newly cloned vertebrate homologue of the Drosophila protein Smoothened (vSmo), and that vSmo is coexpressed with vPtc in many tissues but does not bind Shh directly.