The challenge of cyclic and acyclic schiff bases and related derivatives

From mononuclear to polynuclear macrocyclic or macroacyclic complexes

1,10-Phenanthroline: a versatile ligand

1,10-Phenanthroline: a versatile building block for the construction of ligands for various purposes

The synthesis, lanthanide complexation, and solvent extraction of actinide(III) and lanthanide(III) radiotracers from nitric acid solutions by a phenanthroline-derived quadridentate bis-triazine ligand are described The ligand separates Am(III) and Cm(III) from the lanthanides with remarkably high efficiency, high selectivity, and fast extraction kinetics compared to its 2,2′-bipyridine counterpart Structures of the 1:2 bis-complexes of the ligand with Eu(III) and Yb(III) were elucidated by X-ray crystallography and force field calculations, respectively The Eu(III) bis-complex is the first 1:2 bis-complex of a quadridentate bis-triazine ligand to be characterized by crystallography The faster rates of extraction were verified by kinetics measurements using the rotating membrane cell technique in several diluents The improved kinetics of metal ion extraction are related to the higher surface activity of the ligand at the phase interface The improvement in the ligand's properties on replacing the bip

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Highly Efficient Separation of Actinides from Lanthanides by a Phenanthroline-Derived Bis-triazine Ligand

Synthesis of some 2,9‐disubstituted‐1,10‐phenanthrolines

The synthesis of macrocyclic polyether-diesters incorporating 1,10-phenanthrolino and 1,8-naphthyridino subunits

Macrocyclic polyether- and polythioether-diesters and dithioesters from 1,10-phenanthroline-2,9-dicarboxylic acid

The synthesis is reported of the bis-daunomycin derivatives (5a–g) which have been shown conclusively to act as bis-intercalating agents of DNA and also to exhibit slow DNA-dissociation kinetics.

The synthesis and characterization of a series of bis-intercalating bis-anthracyclines

A new bis-daunomycin has been synthesized and characterized by 13C-n.m.r. and reversed-phase h.p.l.c. The compound was found to be highly self-associated in aqueous solution and to bis-intercalate into DNA with a residence time about 200-fold greater than the parent compound daunomycin. Although the bis-daunomycin and its parent congener were taken up by V79 Chinese hamster ovarian leukaemia cells to similar extents, the cytotoxicity of the former was considerably lower. The possible in vivo relationship between DNA binding affinity and cytotoxicity is discussed.

Christopher J. Chandler

Papers

Synthesis of some 2,9‐disubstituted‐1,10‐phenanthrolines

The synthesis of macrocyclic polyether-diesters incorporating 1,10-phenanthrolino and 1,8-naphthyridino subunits

Macrocyclic polyether- and polythioether-diesters and dithioesters from 1,10-phenanthroline-2,9-dicarboxylic acid

The synthesis and characterization of a series of bis-intercalating bis-anthracyclines

The DNA-association and biological activity of a new bis(14-thiadaunomycin).