Christopher J. Nicolai

TL;DR: It is revealed that NK cells, in addition to T cells, mediate the effect of PD-1/PD-L1 blockade immunotherapy, and the importance of this axis in inhibiting NK cell responses in vivo is demonstrated.

TL;DR: Powerful CDN-induced, natural killer (NK) cell–mediated tumor rejection in numerous tumor models, independent of CD8+ T cells is demonstrated.

TL;DR: It is proposed that the Lgt and SidE families of effectors work in concert to liberate host amino acids for consumption by L. pneumophila, and that a common activity of both effector families is to inhibit host translation.

TL;DR: The characteristics that allow ID-VP02 to specifically transduce human DCs, and the advances that ID- VP02 brings to conventional third-generation lentiviral vector design are described as well as demonstrate upstream production yields that will enable manufacturing feasibility studies to be conducted.

TL;DR: This work takes a distinct approach of sensitizing surface radiation against minute temperature variation of the object, and refined the NEDT by over 15 times with the TIS to achieve single-digit millikelvin resolution near room temperature, empowering ambient thermography for a broad range of applications.