K
Karen Jardine
Researcher at Ottawa Hospital Research Institute
Publications - 39
Citations - 3280
Karen Jardine is an academic researcher from Ottawa Hospital Research Institute. The author has contributed to research in topics: Gene & Transgene. The author has an hindex of 24, co-authored 39 publications receiving 2988 citations. Previous affiliations of Karen Jardine include University of Ottawa.
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Journal ArticleDOI
The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis
Michael W. McBurney,Xiaofeng Yang,Karen Jardine,Mary L. Hixon,Kim Boekelheide,John R. Webb,Peter M. Lansdorp,Madeleine E. Lemieux +7 more
TL;DR: No evidence for failure of gene silencing is found in sir2α null animals, suggesting that either SIR2α has a different role in mammals than it does in Saccharomyces cerevisiae or that its role in genesilencing in confined to a small subset of mammalian genes.
Journal ArticleDOI
Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade
Joy Hsu,Jonathan J. Hodgins,Malvika Marathe,Christopher J. Nicolai,Marie-Claude Bourgeois-Daigneault,Marie-Claude Bourgeois-Daigneault,Troy N. Trevino,Camillia S. Azimi,Amit Scheer,Amit Scheer,Haley E. Randolph,Thornton W Thompson,Lily Zhang,Alexandre Iannello,Nikhita Mathur,Nikhita Mathur,Karen Jardine,Karen Jardine,Georgia A. Kirn,John C. Bell,John C. Bell,Michael W. McBurney,Michael W. McBurney,David H. Raulet,Michele Ardolino,Michele Ardolino,Michele Ardolino +26 more
TL;DR: It is revealed that NK cells, in addition to T cells, mediate the effect of PD-1/PD-L1 blockade immunotherapy, and the importance of this axis in inhibiting NK cell responses in vivo is demonstrated.
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SirT1 regulates energy metabolism and response to caloric restriction in mice.
Gino Boily,Erin L. Seifert,Lisa Bevilacqua,Xiao Hong He,Guillaume Sabourin,Carmen Estey,Cynthia Moffat,Sean A. Crawford,Sarah Saliba,Karen Jardine,Jian Xuan,Meredith Evans,Mary-Ellen Harper,Michael W. McBurney +13 more
TL;DR: SirT1 is an important regulator of energy metabolism and, like its orthologues from simpler eukaryotes, the SirT1 protein appears to be required for a normal response to caloric restriction.
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The mouse Pgk-1 gene promoter contains an upstream activator sequence.
Michael W. McBurney,Leslie C. Sutherland,Chakar N. Adra,Benoit Leclair,Michael A. Rudnicki,Karen Jardine +5 more
TL;DR: The Pgk-1 gene encodes the housekeeping enzyme, 3-phosphoglycerate kinase, and is ubiquitously expressed and the 120 bp upstream of the transcription start site functions as a core promoter, which enhances transcription from the core promoter in an orientation and position independent fashion.
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SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
TL;DR: SirT1 does not behave like a classical tumor-suppressor gene but the antitumor activity of resveratrol is mediated at least in part by SirT1, suggesting that part of the protection afforded by resver atrol requires the SirT 1-encoded protein.