C
Christopher J. Smith
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 73
Citations - 3449
Christopher J. Smith is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Autism & Autism spectrum disorder. The author has an hindex of 31, co-authored 71 publications receiving 3185 citations. Previous affiliations of Christopher J. Smith include Veterans Health Administration & Barrow Neurological Institute.
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Journal ArticleDOI
Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity
Joseph D. Buxbaum,Jeremy M. Silverman,Christopher J. Smith,Mario Kilifarski,Jennifer Reichert,Eric Hollander,Brian A. Lawlor,Michael Fitzgerald,David A. Greenberg,Kenneth L. Davis +9 more
TL;DR: The increased scores in the restricted sample, together with evidence for heterogeneity in the entire sample, indicate that therestricted sample comprises a population that is more genetically homogeneous, which could therefore increase the likelihood of positional cloning of susceptibility loci.
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Association between a GABRB3 polymorphism and autism.
Joseph D. Buxbaum,Jeremy M. Silverman,Christopher J. Smith,David A. Greenberg,Mario Kilifarski,Jennifer Reichert,Edwin H. Cook,Fang Y,C.-Y. Song,R. Vitale +9 more
TL;DR: Findings support a role for genetic variants within the GABA receptor gene complex in 15q11–13 in autistic disorder, and use of multi-allelic TDT (MTDT) and transmission disequilibrium test (TDT) demonstrated an association between autistic disorder and 155CA-2 in these families.
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Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly
Joseph D. Buxbaum,Guiqing Cai,Pauline Chaste,Gudrun Nygren,Juliet Goldsmith,Jennifer Reichert,Henrik Anckarsäter,Maria Råstam,Christopher J. Smith,Jeremy M. Silverman,Eric Hollander,Marion Leboyer,Christopher Gillberg,Alain Verloes,Catalina Betancur +14 more
TL;DR: It is suggested that PTEN mutations are a relatively infrequent cause of ASDs with macrocephaly, even in the absence of other features of PTEN‐related tumor syndromes.
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Linkage and Association of the Mitochondrial Aspartate/Glutamate Carrier SLC25A12 Gene With Autism
Nicolas Ramoz,Jennifer Reichert,Christopher J. Smith,Jeremy M. Silverman,Irina N. Bespalova,Kenneth L. Davis,Joseph D. Buxbaum +6 more
TL;DR: A strong association of autism with SNPs within the SLC25A12 gene was demonstrated and any potential etiological role of AGC1 in autism was identified.
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Linkage analysis for autism in a subset families with obsessive-compulsive behaviors: evidence for an autism susceptibility gene on chromosome 1 and further support for susceptibility genes on chromosome 6 and 19.
Joseph D. Buxbaum,Jeremy M. Silverman,M Keddache,Christopher J. Smith,Eric Hollander,Nicolas Ramoz,Jennifer Reichert +6 more
TL;DR: In this paper, a linkage analysis was carried out in a sample of 62 autism-affected relative pairs with more severe obsessive-compulsive behaviors, selected from a larger (n=115) set of autism-associated relative pairs as a means of reducing sample heterogeneity.