C
Christopher M. Fanger
Researcher at University of California, Irvine
Publications - 8
Citations - 1262
Christopher M. Fanger is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Calcium signaling & Jurkat cells. The author has an hindex of 8, co-authored 8 publications receiving 1222 citations.
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Journal ArticleDOI
Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice
Malcolm A. Leissring,Yama Akbari,Christopher M. Fanger,Michael D. Cahalan,Mark P. Mattson,Frank M. LaFerla +5 more
TL;DR: The overfilling of calcium stores represents the fundamental cellular defect underlying the alterations in calcium signaling conferred by presenilin mutations, and is suggested to be the cause of brain aging and Alzheimer's disease.
Journal ArticleDOI
Calmodulin Mediates Calcium-dependent Activation of the Intermediate Conductance KCa Channel,IKCa1 *
Christopher M. Fanger,Sanjiv Ghanshani,Naomi J. Logsdon,Heiko Rauer,K. Kalman,Jianming Zhou,Kathy Beckingham,K. George Chandy,Michael D. Cahalan,Jayashree Aiyar +9 more
TL;DR: The results suggest that Ca2+-calmodulin-induced conformational changes in all four subunits are necessary for the channel to open.
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A Nongenomic Mechanism for Progesterone-mediated Immunosuppression: Inhibition of K+ Channels, Ca2+ Signaling, and Gene Expression in T Lymphocytes
George R. Ehring,Hubert H. Kerschbaum,C Eder,AL Neben,Christopher M. Fanger,RM Khoury,PA Negulescu,Cahalan +7 more
TL;DR: Using human T lymphocytes and T cell lines, it is shown that progesterone rapidly and reversibly blocks voltage-gated and calcium-activated K+ channels (KV and KCa, respectively), resulting in depolarization of the membrane potential.
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Calcium-activated Potassium Channels Sustain Calcium Signaling in T Lymphocytes SELECTIVE BLOCKERS AND MANIPULATED CHANNEL EXPRESSION LEVELS
Christopher M. Fanger,Heiko Rauer,Amber L. Neben,Mark J. Miller,Heike Rauer,Heike Wulff,Joaquin Campos Rosa,C. Robin Ganellin,K. George Chandy,Michael D. Cahalan +9 more
TL;DR: This work demonstrates that Ca2+-activated K+ channels, hSKCa2 in the human leukemic T cell line Jurkat and hIKCa1 in mitogen-activated human T cells, play a vital role in T cell Ca2- signaling.
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Differential Ca2+ Influx, KCa Channel Activity, and Ca2+ Clearance Distinguish Th1 and Th2 Lymphocytes
TL;DR: Investigation of other mechanisms controlling the concentration of intracellular Ca2+, including K+ channels and Ca2+ clearance from the cytosol of both cell types found that Th2 cells extrude Ca2- more quickly than Th1 cells, suggesting a combination of a faster Ca2+.