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Christopher P. Shelburne
Researcher at Duke University
Publications - 24
Citations - 1570
Christopher P. Shelburne is an academic researcher from Duke University. The author has contributed to research in topics: Mast cell & Cytokine. The author has an hindex of 16, co-authored 24 publications receiving 1509 citations. Previous affiliations of Christopher P. Shelburne include Virginia Commonwealth University & VCU Medical Center.
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Journal ArticleDOI
Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.
James B. McLachlan,Justin P. Hart,Salvatore V. Pizzo,Christopher P. Shelburne,Herman F. Staats,Michael D. Gunn,Soman N. Abraham +6 more
TL;DR: It is shown that draining lymph nodes of mast cell-deficient mice did not demonstrate swelling after intradermal bacterial challenge, and a critical function for peripheral mast cell–derived tumor necrosis factor in regulating the hypertrophy of draining lymph node during infection is shown.
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Mast cell activators: a new class of highly effective vaccine adjuvants
James B. McLachlan,Christopher P. Shelburne,Justin P. Hart,Salvatore V. Pizzo,Rajen Goyal,Rhea Brooking-Dixon,Herman F. Staats,Soman N. Abraham +7 more
TL;DR: It is demonstrated that subcutaneous or nasal administration of small-molecule MC activators with vaccine antigens evokes large increases in antigen-specific serum immunoglobulin G (IgG) responses, which define the MC as an integral sensory arm of the adaptive immune system.
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Stat5 expression is critical for mast cell development and survival.
Christopher P. Shelburne,Margaret E. McCoy,Roland P. Piekorz,Veronika Sexl,Kwan-ho Roh,Sarah M. Jacobs-Helber,Sheila R. Gillespie,Daniel P. Bailey,Paria Mirmonsef,Meredith N. Mann,Mohit Kashyap,Harry V. Wright,Hey Jin Chong,L.Andrew Bouton,Brian O. Barnstein,Carlos Ramírez,Kevin D. Bunting,Stephen T. Sawyer,Chris S. Lantz,John J. Ryan +19 more
TL;DR: Results indicate that Stat5A and Stat5B are critical regulators of in vitro and in vivo mast cell development and survival.
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Mast Cells Augment Adaptive Immunity by Orchestrating Dendritic Cell Trafficking through Infected Tissues
Christopher P. Shelburne,Hideki Nakano,Ashley L. St. John,Cheryl Y. Chan,James B. McLachlan,Michael D. Gunn,Herman F. Staats,Soman N. Abraham +7 more
TL;DR: During footpad infection with E. coli in MC-deficient mice, the serum antibody response is significantly diminished and less protective following passive immunization in a urinary tract infection (UTI) model in wild-type mice.
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Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis
C. Fitzhugh Yeatman,Sarah M. Jacobs-Helber,Paria Mirmonsef,Sheila R. Gillespie,Lawrence Andrew Bouton,Henrietta A. Collins,Stephen T. Sawyer,Christopher P. Shelburne,John J. Ryan +8 more
TL;DR: Evidence is offered of Th2 cytokine–mediated homeostasis whereby these cytokines both elicit and limit allergic responses and Dysregulation of this pathway may play a role in allergic disease and mast cell tumor survival.