Christopher S. Raymond

TL;DR: The male sexual regulatory gene mab-3 from the nematode Caenorhabditis elegans is isolated and found that it is related to the Drosophila melanogasterSexual regulatory gene doublesex (dsx), which encodes proteins with a DNA-binding motif that is named the ‘DM domain’.

TL;DR: It is shown that murine Dmrt1 is essential for postnatal testis differentiation, with mutant phenotypes similar to those caused by human chromosome 9p deletions that remove the gene.

TL;DR: Based on sequence, map position, and expression patterns, it is suggested that Dmrt1 is likely to play a role in vertebrate sexual development and therefore that DM domain genes may play a roles in sexual development in a wide range of phyla.

TL;DR: It is shown by fluorescence in situ hybridization analysis that both genes are deleted in the smallest reported sex-reversing 9p deletion, suggesting that gonadal dysgenesis in 9p-deleted individuals might be due to combined hemizygosity of D MRT1 and DMRT2.

TL;DR: In this article, the authors examined the expression of the Dmrt1 gene, a candidate regulator of mammalian and avian sexual development, in the turtle, and found that during the sex-determining period, the gene was more abundant in the genital ridge/mesonephros complexes at male-promoting than at female-enhancing temperatures.