C
Chuanyue Wu
Researcher at University of Pittsburgh
Publications - 173
Citations - 12329
Chuanyue Wu is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Integrin-linked kinase & Focal adhesion. The author has an hindex of 59, co-authored 166 publications receiving 11377 citations. Previous affiliations of Chuanyue Wu include Carnegie Mellon University & Scripps Research Institute.
Papers
More filters
Journal ArticleDOI
Breaking the Integrin Hinge A DEFINED STRUCTURAL CONSTRAINT REGULATES INTEGRIN SIGNALING
Paul E. Hughes,Federico Díaz-González,Lilley Leong,Chuanyue Wu,John A. McDonald,Sanford J. Shattil,Mark H. Ginsberg +6 more
TL;DR: In this paper, the authors demonstrate that point mutations in the cytoplasmic domains of both the alpha and beta subunits promote constitutive signaling by the integrin alphaIIbbeta3.
Journal ArticleDOI
Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
Chuanyue Wu,Shoukat Dedhar +1 more
TL;DR: The molecular activities and cellular functions of ILK, a protein that is emerging as a key component of the cell–ECM adhesion structures, are discussed.
Journal ArticleDOI
Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.
TL;DR: It is shown that migfilin, a LIM-containing protein, localizes to cell-matrix adhesions, associates with actin filaments, and is essential for cell shape modulation.
Journal ArticleDOI
Kindlin-2 (Mig-2): a co-activator of β3 integrins
TL;DR: This work shows that the C-terminal region of integrin β3 CT, composed of a conserved TS752T region and NITY759 motif, supports integrin activation by binding to a cytosolic binding partner, kindlin-2, a widely distributed PTB domain protein.
Journal ArticleDOI
Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix.
TL;DR: A model for integrin involvement in Fn fibrillogenesis is proposed that reconciles previous paradoxes and suggests novel approaches to the therapeutic control of Fn matrix assembly.