E
Edward F. Plow
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 453
Citations - 42036
Edward F. Plow is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Integrin & Platelet. The author has an hindex of 110, co-authored 442 publications receiving 40241 citations. Previous affiliations of Edward F. Plow include Case Western Reserve University & Food and Drug Administration.
Papers
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Journal ArticleDOI
Ligand binding to integrins.
TL;DR: The number of integrins and the remarkable breadth of their cellular distribution support the statement that the phenotype of virtually every cell is uniquely influenced by its display ofintegrins.
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Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors
TL;DR: The results establish the existence of a family of adhesion receptors that recognize the sequence Arg-Gly-Asp, which corresponds to the cell adhesion site in fibronectin and is also present in the alpha chain of fibrinogen.
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Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine.
TL;DR: Platelets have a key role in atherosclerosis, thrombosis, and acute coronary syndromes and therapeutic manipulation of platelet function has focused principally on the use of aspirin.
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Human platelets possess an inducible and saturable receptor specific for fibrinogen
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The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets.
Edward F. Plow,Michael D. Pierschbacher,Erkki I. Ruoslahti,Gérard Marguerie,Mark H. Ginsberg +4 more
TL;DR: In this paper, the effects of Arg-Gly-Asp-containing peptides on the interaction of these latter two adhesive proteins with platelets were examined, and it was shown that the peptide was 1/2 to 1/3rd as potent in inhibiting fibrinogen as fibronectin binding to platelets.