C
Chun Luo
Researcher at Harvard University
Publications - 8
Citations - 4183
Chun Luo is an academic researcher from Harvard University. The author has contributed to research in topics: NFAT & Transcription factor. The author has an hindex of 8, co-authored 8 publications receiving 4062 citations. Previous affiliations of Chun Luo include Oregon Health & Science University.
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Journal ArticleDOI
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
TL;DR: Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed.
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Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
Patricia G. McCaffrey,Chun Luo,Tom K. Kerppola,Jugnu Jain,Tina M. Badalian,Andrew M. Ho,Emmanuel Burgeon,William S. Lane,John Lambert,Tom Curran,Gregory L. Verdine,Anjana Rao,Patrick G. Hogan +12 more
TL;DR: The molecular cloning of NFATp should allow detailed analysis of a T cell transcription factor that is central to initiation of the immune response.
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An enhanced immune response in mice lacking the transcription factor NFAT1.
Steven Xanthoudakis,João P. B. Viola,Karen T. Y. Shaw,Chun Luo,James D. Wallace,Patrícia T. Bozza,Tom Curran,Anjana Rao +7 more
TL;DR: Results suggest that NFAT1 exerts a negative regulatory influence on the immune response, and in an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased.
Journal ArticleDOI
Calcineurin binds the transcription factor nfat1 and reversibly regulates its activity
Christine Loh,Karen T. Y. Shaw,Josephine A. Carew,João P. B. Viola,Chun Luo,Brian A. Perrino,Anjana Rao +6 more
TL;DR: It is shown that the activation state of NFAT1 in T cells is remarkably sensitive to the level of calcineurin activity, and an N-terminal region ofNFAT1 conserved in other NFAT family proteins may provide a target for the design of novel immunosuppressive drugs.
Journal ArticleDOI
Recombinant NFAT1 (NFATp) Is Regulated by Calcineurin in T Cells and Mediates Transcription of Several Cytokine Genes
Chun Luo,Emmanuel Burgeon,Josephine A. Carew,Patricia G. McCaffrey,Tina M. Badalian,William S. Lane,Patrick G. Hogan,Andanjana Rao +7 more
TL;DR: Recombinant NFAT1 can mediate transcription of the interleukin-2, interleUKin-4, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor promoters in T cells, suggesting thatNFAT1 contributes to the CsA-sensitive transcription of these genes during the immune response.