C
Chunderika Mocktar
Researcher at University of KwaZulu-Natal
Publications - 74
Citations - 1674
Chunderika Mocktar is an academic researcher from University of KwaZulu-Natal. The author has contributed to research in topics: Drug delivery & Antibacterial activity. The author has an hindex of 18, co-authored 66 publications receiving 1062 citations.
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Journal ArticleDOI
Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy
TL;DR: An extensive review of several antibiotic-loaded nanocarriers that have been formulated to target drugs to infectious sites, achieve controlled drug release profiles, and address formulation challenges, such as low-drug entrapment efficiencies, poor solubility and stability is presented.
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Solid lipid nanoparticles of clotrimazole silver complex: An efficient nano antibacterial against Staphylococcus aureus and MRSA.
Rahul S. Kalhapure,Sandeep J. Sonawane,Dhiraj R. Sikwal,Mahantesh Jadhav,Sanjeev Rambharose,Chunderika Mocktar,Thirumala Govender +6 more
TL;DR: Clotrimazole-silver SLNs was found to be an efficient nanoantibiotic for enhanced and sustained antibacterial activity against susceptible and resistant Staphylococcus aureus and methicillin-resistant S. aUREus.
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Ion pairing with linoleic acid simultaneously enhances encapsulation efficiency and antibacterial activity of vancomycin in solid lipid nanoparticles
Rahul S. Kalhapure,Chunderika Mocktar,Dhiraj R. Sikwal,Sandeep J. Sonawane,Muthu K. Kathiravan,Adam A. Skelton,Thirumala Govender +6 more
TL;DR: It is suggested that VCM-LA2_SLNs is a promising nanoantibiotic system for effective treatment against both sensitive and resistant S. aureus infections.
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Enhancing targeted antibiotic therapy via pH responsive solid lipid nanoparticles from an acid cleavable lipid.
Rahul S. Kalhapure,Dhiraj R. Sikwal,Sanjeev Rambharose,Chunderika Mocktar,Sanil D. Singh,Linda A. Bester,Jung Kwon Oh,Jwala Renukuntla,Thirumala Govender +8 more
TL;DR: This study confirmed that SA-3M can form pH-responsive SLNs capable of releasing antibiotic specifically at acidic infection sites.
Journal ArticleDOI
Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid–polymer hybrid nanoparticles: In vitro and in silico studies
Nasreen Seedat,Rahul S. Kalhapure,Chunderika Mocktar,Suresh B. Vepuri,Mahantesh Jadhav,Mahmoud E. S. Soliman,Thirumala Govender +6 more
TL;DR: Results indicated rod-shaped LPNs with suitable size, PDI and zeta potential, while encapsulation efficiency increased from 27.8% to 41.3% with the addition of OA, CHT and ALG respectively, proves to be a promising system for delivery of VCM as well as other antibiotics.