C
Chungho Kim
Researcher at Korea University
Publications - 57
Citations - 3601
Chungho Kim is an academic researcher from Korea University. The author has contributed to research in topics: Integrin & Integrin, beta 6. The author has an hindex of 20, co-authored 52 publications receiving 3153 citations. Previous affiliations of Chungho Kim include Seoul National University Hospital & New Generation University College.
Papers
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Journal ArticleDOI
The final steps of integrin activation: the end game
TL;DR: Recent progress provides insight into the structure of integrin transmembrane domains, and reveals how the final steps of Integrin activation are mediated by integrin-binding proteins such as talins and kindlins.
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Regulation of Integrin Activation
TL;DR: Recent progress in understanding how the membrane environment can, in cooperation with integrin-binding proteins, regulate integrin activation is reviewed.
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The structure of an integrin/talin complex reveals the basis of inside‐out signal transduction
Nicholas J. Anthis,Kate L. Wegener,Feng Ye,Chungho Kim,Benjamin T. Goult,Edward D. Lowe,Ioannis Vakonakis,Neil Bate,David R. Critchley,Mark H. Ginsberg,Iain D. Campbell +10 more
TL;DR: This work reports the first structure of talin bound to an authentic full‐length β integrin tail and identifies a positively charged surface on the talin F2 domain that precisely orients talin to disrupt the heterodimeric integrin transmembrane (TM) complex.
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The structure of the integrin αIIbβ3 transmembrane complex explains integrin transmembrane signalling
TL;DR: The structure of the integrin αIIbβ3 TM complex is reported, structure‐based site‐directed mutagenesis and lipid embedding estimates revealed to reveal the structural event that underlies the transition from associated to dissociated states, that is, TM signalling.
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Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells
Eugene Tkachenko,Mohsen Sabouri-Ghomi,Olivier Pertz,Chungho Kim,Edgar Gutierrez,Matthias Machacek,Alex Groisman,Gaudenz Danuser,Gaudenz Danuser,Mark H. Ginsberg +9 more
TL;DR: Live-cell imaging of biosensors is used to monitor spontaneous morphodynamic and signalling activities, and correlative image analysis is employed to examine the role of cyclic-AMP-activated protein kinase A (PKA) in protrusion regulation.