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Chunmei Chen
Researcher at Huazhong University of Science and Technology
Publications - 132
Citations - 1871
Chunmei Chen is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 20, co-authored 106 publications receiving 1269 citations. Previous affiliations of Chunmei Chen include Southwest University.
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Journal ArticleDOI
Asperchalasine A, a Cytochalasan Dimer with an Unprecedented Decacyclic Ring System, from Aspergillus flavipes
Hucheng Zhu,Chunmei Chen,Yongbo Xue,Qingyi Tong,Xiao-Nian Li,Xintao Chen,Jianping Wang,Guangmin Yao,Zengwei Luo,Yonghui Zhang +9 more
TL;DR: 1 induced significant G1-phase cell cycle arrest by selectively inhibiting cyclin A, CDK2 and CDK6 in cancerous, but not normal, cells, highlighting it as a potentially selective cell cycle regulator against cancer cells.
Journal ArticleDOI
Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii
Hucheng Zhu,Chunmei Chen,Jing Yang,Xiao-Nian Li,Junjun Liu,Bin Sun,Sheng-Xiong Huang,Dongyan Li,Guangmin Yao,Zengwei Luo,Yan Li,Jinwen Zhang,Yongbo Xue,Yonghui Zhang +13 more
TL;DR: Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 μM and selectivity index of 4.3.70 and 7.1.70, respectively.
Journal ArticleDOI
Epicochalasines A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes
Hucheng Zhu,Chunmei Chen,Qingyi Tong,Xiao-Nian Li,Jing Yang,Yongbo Xue,Zengwei Luo,Jianping Wang,Guangmin Yao,Yonghui Zhang +9 more
TL;DR: It is found that merocytochalasans induce apoptosis in leukemia cells through the activation of caspase-3 and the degradation of PARP, and is proposed to involve Diels-Alder and nucleophilic addition reactions.
Journal ArticleDOI
Asperflavipine A: A Cytochalasan Heterotetramer Uniquely Defined by a Highly Complex Tetradecacyclic Ring System from Aspergillus flavipes QCS12
Hucheng Zhu,Chunmei Chen,Qingyi Tong,Jing Yang,Guangzheng Wei,Yongbo Xue,Jianping Wang,Zengwei Luo,Yonghui Zhang +8 more
TL;DR: Compound 1 showed moderate cytotoxicity and induced apoptosis in Jurkat, NB4, and HL60 cells through the activation of caspase-3 and degradation of poly(ADP-ribose) polymerase (PARP), and adds a new dimension to the diversity of the cytochalasan family.
Journal ArticleDOI
Armochaetoglobins A-J: Cytochalasan Alkaloids from Chaetomium globosum TW1-1, a Fungus Derived from the Terrestrial Arthropod Armadillidium vulgare.
Chunmei Chen,Jianping Wang,Junjun Liu,Hucheng Zhu,Bin Sun,Jing Wang,Jinwen Zhang,Zengwei Luo,Guangmin Yao,Yongbo Xue,Yonghui Zhang +10 more
TL;DR: Ten new cytochalasan alkaloids, termed armochaetoglobins A-J (1-10), and four known chaetoglobosins (11-14) were isolated from a methanol extract of Chaetomium globosum TW1-1, a fungus isolated from the medicinal terrestrial arthropod Armadillidium vulgare.