J
Junjun Liu
Researcher at Huazhong University of Science and Technology
Publications - 155
Citations - 3731
Junjun Liu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Chemistry & Polyketide. The author has an hindex of 30, co-authored 142 publications receiving 2914 citations. Previous affiliations of Junjun Liu include University of Michigan & University of Kentucky.
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Journal ArticleDOI
The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin.
Paola Bargagna-Mohan,Adel Hamza,Yang-eon Kim,Yik Khuan Ho,Nirit Mor-Vaknin,Nicole Wendschlag,Junjun Liu,Robert M. Evans,David M. Markovitz,Chang-Guo Zhan,Kyung Bo Kim,Royce Mohan +11 more
TL;DR: It is shown that WFA binds to the intermediate filament (IF) protein, vimentin, by covalently modifying its cysteine residue, which is present in the highly conserved alpha-helical coiled coil 2B domain.
Journal ArticleDOI
Most Efficient Cocaine Hydrolase Designed by Virtual Screening of Transition States
Fang Zheng,Wen-Chao Yang,Mei-Chuan Ko,Junjun Liu,Hoon Cho,Daquan Gao,Min Tong,Hsin Hsiung Tai,James H. Woods,Chang-Guo Zhan +9 more
TL;DR: The novel computational design approach has led to discovery of the most efficient cocaine hydrolase, i.e., a human BChE mutant with an approximately 2000-fold improved catalytic efficiency, promising for therapeutic treatment of cocaine overdose and addiction as an exogenous enzyme in human.
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Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A
Zhengxi Hu,Ye Wu,Shuangshuang Xie,Weiguang Sun,Yi Guo,Xiao-Nian Li,Junjun Liu,Hua Li,Jianping Wang,Zengwei Luo,Yongbo Xue,Yonghui Zhang +11 more
TL;DR: Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp.
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Design, Preparation, and Characterization of High-Activity Mutants of Human Butyrylcholinesterase Specific for Detoxification of Cocaine
Liu Xue,Mei-Chuan Ko,Min Tong,Wen-Chao Yang,Shurong Hou,Lei Fang,Junjun Liu,Fang Zheng,James H. Woods,Hsin-Hsiung Tai,Chang-Guo Zhan +10 more
TL;DR: Two representative BChE mutants have been confirmed to be potent in actual protection of mice from acute toxicity of a lethal dose of cocaine (180 mg/kg) and future direction for further improving the efficacy of the enzyme in the cocaine overdose treatment is revealed.
Journal ArticleDOI
Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum Sampsonii
Hucheng Zhu,Chunmei Chen,Jing Yang,Xiao-Nian Li,Junjun Liu,Bin Sun,Sheng-Xiong Huang,Dongyan Li,Guangmin Yao,Zengwei Luo,Yan Li,Jinwen Zhang,Yongbo Xue,Yonghui Zhang +13 more
TL;DR: Hyperisampsins A and D showed potent anti-HIV activities with EC50 of 2.97 and 0.97 μM and selectivity index of 4.3.70 and 7.1.70, respectively.