Cinzia Ferri

TL;DR: Findings suggested that detectable levels of circulating cytokines and increased ACT might not be derived by activation of peripheral immune system of AD patients, and detection of these molecules might be used for monitoring the progression of brain inflammation associated with AD.

TL;DR: Overexpression of the pluripotent cytokine interleukin‐1 by microglial cells correlates with formation of neuritic β‐amyloid plaques in Alzheimer's disease, and data suggest either a direct effect of the IL‐1 gene family on the clinical onset of AD, or a linkage dysequilibrium with an unknown locus relevant to AD on chromosome 2.

TL;DR: Plasma levels of α1‐antichymotrypsin (ACT) and inter‐leukin‐1 β (IL‐1β) were increased in patients with probable Alzheimer's disease (AD) and AD patients with the ACT T,T or IL-1β T, t,T genotype showed the highest levels of plasma ACT or IL‐ 1β, respectively.

TL;DR: It is found that Egr2/Krox20 and SREBP transactivators can synergistically activate promoters of several SRE BP target genes, indicating that direct induction of cholesterol/lipid biosynthetic genes by Egr 2/ Krox20 is a part of the myelination program regulated by this transactivator.

TL;DR: It is concluded that an IL-1Ra gene polymorphism is associated with occurrence of disease and clinical course variability in Italian MS patients.