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Claire Heride
Researcher at University of Liverpool
Publications - 14
Citations - 983
Claire Heride is an academic researcher from University of Liverpool. The author has contributed to research in topics: Ubiquitin & Ubiquitin ligase. The author has an hindex of 8, co-authored 14 publications receiving 767 citations. Previous affiliations of Claire Heride include French Alternative Energies and Atomic Energy Commission.
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Journal ArticleDOI
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Andrew P. Turnbull,Stephanos Ioannidis,Wojciech W. Krajewski,Adan Pinto-Fernandez,Claire Heride,Agnes C. L. Martin,Louise M. Tonkin,Elizabeth C. Townsend,Shane M. Buker,David R. Lancia,Caravella Justin Andrew,Angela V. Toms,Thomas M. Charlton,Johanna Lahdenranta,Erik W. Wilker,Bruce Follows,Nicola J. Evans,Lucy Stead,Cristina Alli,Vladislav V. Zarayskiy,Adam C. Talbot,Alexandre J. Buckmelter,Minghua Wang,Crystal McKinnon,Fabienne Saab,Joanna F. McGouran,Hannah Century,Malte Gersch,Marc S. Pittman,C. Gary Marshall,Tony Raynham,Mary Simcox,Lorna M. D. Stewart,Sheila B. McLoughlin,Jaime Escobedo,Kenneth W. Bair,Christopher J. Dinsmore,Tim Hammonds,Sunkyu Kim,Sylvie Urbé,Michael J. Clague,Benedikt M. Kessler,David Komander +42 more
TL;DR: Two compounds are reported that inhibit ubiquitin-specific protease 7 with high affinity and specificity in vitro and within human cells, and co-crystal structures reveal that both compounds target a dynamic pocket near the catalytic centre of the auto-inhibited apo form of USP7, which differs from other USP deubiquitinases.
Journal ArticleDOI
The demographics of the ubiquitin system.
TL;DR: The emerging picture of the most significant determinants of the cellular ubiquitin economy is delineated, which includes E1, E2, and E3s, which represents ∼1.3% of total cellular protein.
Journal ArticleDOI
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions
TL;DR: Functional data suggest a key role for USP21 in the choreography of microtubule reorganization.
Journal ArticleDOI
Ubiquitin code assembly and disassembly.
TL;DR: It is considered here how this view has evolved to appreciate that the dynamic appendage of different types of ubiquitin chains represents a versatile, three-dimensional code, fundamental to the control of many cellular processes.
Journal ArticleDOI
Telomeres: hallmarks of radiosensitivity.
TL;DR: It is postulate that the major impact of the loss of telomere integrity might occur in the long term, during multistep carcinogenesis, to act as an amplificator event unmasking in one single step recessive radiation-induced mutations among thousands of genes and providing cellular proliferative advantage.