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Claire L. Price
Researcher at Swansea University
Publications - 14
Citations - 555
Claire L. Price is an academic researcher from Swansea University. The author has contributed to research in topics: Azole & Itraconazole. The author has an hindex of 9, co-authored 13 publications receiving 405 citations.
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Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens.
TL;DR: An overview of the problem is given and the mechanisms that mediate azole resistance in agriculture are discussed (point mutations in the CYP51 amino acid sequence, overexpression of the CyP51 enzyme and overexpressing of genes encoding efflux pump proteins).
Journal ArticleDOI
Resistance to antifungals that target CYP51
Josie E. Parker,Andrew G. S. Warrilow,Claire L. Price,Jonathan G. L. Mullins,Diane E. Kelly,Steven L. Kelly +5 more
TL;DR: Progress made in understanding azole resistance found amongst clinically and agriculturally important fungal species focussing on resistance mechanisms associated with CYP51 is reviewed.
Journal ArticleDOI
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme
Andrew G. S. Warrilow,Josie E. Parker,Claire L. Price,W. David Nes,Edward P. Garvey,William J. Hoekstra,Robert J. Schotzinger,Diane E. Kelly,Steven L. Kelly +8 more
TL;DR: The cellular mode of action for VT-1129 was confirmed to be CYP51 inhibition, resulting in the depletion of ergosterol and ergosta-7-enol and the accumulation of eburicol, obtusifolione, and lanosterol/obtusIFoliol in the cell membranes.
Journal ArticleDOI
On the occurrence of cytochrome P450 in viruses.
David C. Lamb,Alec H. Follmer,Jared V. Goldstone,David R. Nelson,Andrew G. S. Warrilow,Claire L. Price,Marie Y True,Steven L. Kelly,Thomas L. Poulos,John J. Stegeman +9 more
TL;DR: The findings herald an era of research regarding the evolution of this important gene family, with implications for understanding the biology and the origin of the giant viruses themselves, and present potential drug targets for giant viruses that may be human pathogens.
Journal ArticleDOI
In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus
Andrew G. S. Warrilow,Josie E. Parker,Claire L. Price,W. David Nes,Steven L. Kelly,Diane E. Kelly +5 more
TL;DR: The AfCPR1/Af51 assay system demonstrated the biochemical basis for the increased azole resistance of A. fumigatus strains harboring G54W, L98H, and M220K Af51A point mutations.