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Claire N. Harrison
Researcher at Guy's and St Thomas' NHS Foundation Trust
Publications - 511
Citations - 24605
Claire N. Harrison is an academic researcher from Guy's and St Thomas' NHS Foundation Trust. The author has contributed to research in topics: Ruxolitinib & Myelofibrosis. The author has an hindex of 66, co-authored 424 publications receiving 19843 citations. Previous affiliations of Claire N. Harrison include St Thomas' Hospital & National Health Service.
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Journal ArticleDOI
Results of a prospective, randomized, open-label phase 3 study of ruxolitinib (RUX) in polycythemia vera (PV) patients resistant to or intolerant of hydroxyurea (HU): the RESPONSE trial
Srdan Verstovsek,Jean-Jacques Kiladjian,Martin Griesshammer,Tamas Masszi,Simon Durrant,Francesco Passamonti,Claire N. Harrison,Fabrizio Pane,Pierre Zachee,Ruben A. Mesa,Shui He,Mark M. Jones,William M. Garrett,Jingjin Li,Ulrich Pirron,Tomasz Lawniczek,Alessandro M. Vannucchi +16 more
TL;DR: A myeloproliferative neoplasm characterized by increased erythrocytosis, disease-related symptom burden (eg, pruritus), and risk of vascular events (thrombosis and/or hemorrh... as discussed by the authors.
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STAT1 activation in association with JAK2 exon 12 mutations
Anna L. Godfrey,Edwin Chen,Charles E. Massie,Yvonne Silber,Francesca Pagano,Beatriz Bellosillo,Paola Guglielmelli,Claire N. Harrison,John T. Reilly,Frank Stegelmann,Fontanet Bijou,Eric Lippert,Jean-Michel Boiron,Konstanze Döhner,Alessandro M. Vannucchi,Carlos Besses,Anthony R. Green +16 more
TL;DR: JAK2 exon 12 mutations are associated with more marked and isolated erythrocytosis than JAK2V617F and were associated with interferon-target gene associated with polycythemia vera.
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Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia.
Srdan Verstovsek,Ruben A. Mesa,Moshe Talpaz,Jean-Jacques Kiladjian,Claire N. Harrison,Stephen T. Oh,Alessandro M. Vannucchi,Raajit K. Rampal,Bart L. Scott,Sarah A. Buckley,Adam R. Craig,Karisse Roman-Torres,John Mascarenhas +12 more
TL;DR: In patients with myelofibrosis, ruxolitinib and fedratinib can worsen thrombocytopenia and have not been evaluated in patients with severe THC as mentioned in this paper.
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What is pre-fibrotic myelofibrosis and how should it be managed in 2018?
TL;DR: The main characteristics of this new disease category in view of the current published literature are reviewed, a management strategy for patients to whom this diagnostic label is applied is proposed and some real patient cases are illustrated.
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Full blood count
TL;DR: The full blood count is a fast readily available investigation which adds essential information to clinical assessment of a patient.