Claire N. Harrison

TL;DR: The current document is a revision of the International Working Group-Myeloproliferative Neoplasms Research and Treatment criteria for treatment response in myelofibrosis and represents a collaborative effort by the IWG-MRT and the European LeukemiaNet to objectively assess the value of new drugs in inducing morphologic remission or improvement in MF-associated symptomatic burden.

TL;DR: Results indicate that different pathogenetic mechanisms underlie transformation to JAK2 wild-type and JAK1-mutant AML, show that TET2 mutations may be present in a clone distinct from that harboring aJAK2 mutation, and emphasize the clonal heterogeneity of the MPNs.

TL;DR: This map shows the main referral routes for new admissions to the Royal Infirmary, Gartnavel General Hospital, Glasgow, and Belfast City Hospital.

TL;DR: The high level of acquired skewing of the XCIPs in myeloid cells of the elderly suggests that with time there is a change in stem cell usage with stochastic loss of some of the original stem cells.

TL;DR: The results show that histologic criteria described in the WHO classification are difficult to apply reproducibly and question the validity of distinguishing true ET from prefibrotic myelofibrosis on the basis of subjective morphologic criteria.