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Clara Brieke
Researcher at Max Planck Society
Publications - 29
Citations - 1712
Clara Brieke is an academic researcher from Max Planck Society. The author has contributed to research in topics: Glycopeptide antibiotic & Glycopeptide. The author has an hindex of 17, co-authored 29 publications receiving 1473 citations. Previous affiliations of Clara Brieke include Goethe University Frankfurt.
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Light-Controlled Tools
TL;DR: This Review will focus on developments over the last six years and includes discussions on the underlying technologies as well as their applications.
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X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
TL;DR: It is shown that the presentation of peptidyl carrier protein (PCP)-bound substrates for oxidation in GPA biosynthesis requires the presence of the NRPS X-domain to ensure conversion of the precursor peptide into a mature aglycone, and that the carrier protein domain alone is not always sufficient to generate a competent substrate for external cytochrome P450 oxygenases.
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Light‐Controlled Tools
TL;DR: Light is an ideal external trigger: it is highly selective and if applied correctly also harmless as discussed by the authors, it can be generated and manipulated with well-established techniques, and many ways exist to apply light to living systems.
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Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products
TL;DR: Structures and properties of phenylglycine containing natural products as well as the biosynthetic origin and incorporation of phenolglycines are discussed.
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The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase
Kristina Haslinger,Clara Brieke,Stefanie Uhlmann,Lina Sieverling,Roderich D. Süssmuth,Max J. Cryle +5 more
TL;DR: The structure reveals that complex formation is governed by hydrophobic interactions, the presence of which can be controlled through minor alterations in PCP structure that enable selectivity amongst multiple highly similar PCP domains.