Clark R. Sims

TL;DR: Findings provide evidence for the significant influence of body composition on oocyte transcript abundance in women undergoing hormonal induction to retrieve oocytes and identify the potential for maternal diet to influence oocyte gene expression.

TL;DR: An exercise-induced increase in the oligosaccharide 3′-sialyllactose in milk in humans and mice is identified, and it is shown that the beneficial effects of maternal exercise on mouse offspring’s metabolic health and cardiac function are mediated by3′-SL.

TL;DR: Later in the course of sepsis, pharmacologic stimulation of S1P1, even when delaying therapy until after injury has occurred, improves capillary and renal function, suggesting this approach should be evaluated as an adjunct therapy during sepsi.

TL;DR: These findings demonstrate that infants of OW mothers are exposed to higher concentrations of insulin, leptin, and, to a lesser extent, CRP, and the bioavailability of these 3 human milk bioactives and their mechanisms of action in the infant is unclear.

TL;DR: In this article, the composition of human milk oligosaccharides (HMOs) of women with normal weight (185-249 kg/m2), overweight (250-299 kg/n2), or obesity (300-600 kg/ m2) was quantified and the effect of HMO intake on infant growth was determined.