L
Laurie J. Goodyear
Researcher at Harvard University
Publications - 265
Citations - 36987
Laurie J. Goodyear is an academic researcher from Harvard University. The author has contributed to research in topics: Skeletal muscle & Insulin. The author has an hindex of 92, co-authored 245 publications receiving 33658 citations. Previous affiliations of Laurie J. Goodyear include University of South Carolina & St. John's University.
Papers
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Journal ArticleDOI
Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Margaret E. Griffin,Melissa Marcucci,Gary W. Cline,K. I. M. S. Bell,Nicole Barucci,Dennis Lee,Laurie J. Goodyear,Edward W. Kraegen,Morris F. White,Gerald I. Shulman +9 more
TL;DR: It is concluded that acute elevations of plasma FFA levels for 5 h induce skeletal muscle insulin resistance in vivo via a reduction in insulin-stimulated muscle glycogen synthesis and glucose oxidation that can be attributed to reduced glucose transport activity.
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A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
Jens C. Brüning,M. Dodson Michael,Jonathon N. Winnay,Tatsuya Hayashi,Dieter Hörsch,Domenico Accili,Laurie J. Goodyear,C. Ronald Kahn +7 more
TL;DR: Insulin resistance in muscle contributes to the altered fat metabolism associated with type 2 diabetes, but tissues other than muscle appear to be more involved in insulin-regulated glucose disposal than previously recognized.
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Exercise, glucose transport, and insulin sensitivity.
TL;DR: There is now extensive epidemiological evidence demonstrating that long-term regular physical exercise can significantly reduce the risk of developing non-insulin-dependent diabetes mellitus.
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Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Kristin I. Stanford,Roeland J.W. Middelbeek,Kristy L. Townsend,Ding An,Eva B. Nygaard,Kristen M. Hitchcox,Kathleen R. Markan,Kazuhiro Nakano,Michael F. Hirshman,Yu-Hua Tseng,Laurie J. Goodyear +10 more
TL;DR: A previously under-appreciated role for BAT in glucose metabolism is revealed, demonstrating that BAT-derived IL-6 is required for the profound effects of BAT transplantation on glucose homeostasis and insulin sensitivity.