M
Mark T. Ziolo
Researcher at Ohio State University
Publications - 82
Citations - 3098
Mark T. Ziolo is an academic researcher from Ohio State University. The author has contributed to research in topics: Heart failure & Phospholamban. The author has an hindex of 33, co-authored 75 publications receiving 2667 citations. Previous affiliations of Mark T. Ziolo include Midwestern University & Temple University.
Papers
More filters
Journal ArticleDOI
12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake
Kristin I. Stanford,Matthew D. Lynes,Hirokazu Takahashi,Lisa A. Baer,Peter J. Arts,Francis J. May,Adam C. Lehnig,Roeland J.W. Middelbeek,Jeffrey J. Richard,Kawai So,Emily Y. Chen,Fei Gao,Niven R. Narain,Giovanna Distefano,Vikram Shettigar,Michael F. Hirshman,Mark T. Ziolo,Michael A. Kiebish,Yu-Hua Tseng,Paul M. Coen,Laurie J. Goodyear +20 more
TL;DR: Analysis of lipidomics analysis revealed that a bout of moderate-intensity exercise causes a pronounced increase in the circulating lipid 12,13-dihydroxy-9Z-octadecenoic acid (12, 13-diHOME) in male, female, young, old, sedentary, and active human subjects.
Journal ArticleDOI
Nitric Oxide Signaling and the Regulation of Myocardial Function
TL;DR: This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways.
Journal ArticleDOI
Mechanisms of sex differences in rat cardiac myocyte response to β-adrenergic stimulation
TL;DR: Investigation of sex differences in the functional response of isolated rat heart ventricular myocytes to beta-adrenergic stimulation and in isoproterenol-stimulated signal transduction suggests that cardiac myocytes from male rats have an enhanced response to Beta-adRenergic stimulation due to augmented beta- adrenergic signaling that results in a greater transsarcolemmal Ca(2+) influx.
Journal ArticleDOI
Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies
Joshua J. Oaks,Ramasamy Santhanam,Christopher J. Walker,Steve R. Roof,Jason G. Harb,Greg Ferenchak,Ann-Kathrin Eisfeld,James R. Van Brocklyn,Roger Briesewitz,Sahar A. Saddoughi,Kyosuke Nagata,Robert Bittman,Michael A. Caligiuri,Omar Abdel-Wahab,Ross L. Levine,Ralph B. Arlinghaus,Alfonso Quintás-Cardama,John M. Goldman,Jane F. Apperley,Alistair Reid,Dragana Milojkovic,Mark T. Ziolo,Guido Marcucci,Besim Ogretmen,Paolo Neviani,Danilo Perrotti,Danilo Perrotti +26 more
TL;DR: It is shown here that PADs (eg, FTY720) represent suitable therapeutic alternatives for Jak2(V617F) MPNs, and that PP2A is inactive in polycythemia vera (PV) and other myeloproliferative neoplasms characterized by the expression of the transforming Jak2 (V617f) oncogene.
Journal ArticleDOI
Arrhythmogenic Effects of β2-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load
Jaime DeSantiago,Xun Ai,Mohammed Islam,Georgia Acuna,Mark T. Ziolo,Donald M. Bers,Steven M. Pogwizd +6 more
TL;DR: In an arrhythmogenic rabbit model of HF, it is shown that isoproterenol induces ventricular tachycardia in vivo and aftercontractions and transient inward currents in HF myocytes, and &bgr;2-AR stimulation is arrh rhythmogenic in HF, mediated by SR Ca overload-induced spontaneous SR Ca release and after contractions.