Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)
Guillermo Torre-Amione,Samir R. Kapadia,Claude R. Benedict,Hakan Oral,James B. Young,Douglas L. Mann +5 more
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TLDR
Circulating levels of proinflammatory cytokines increase in patients as their functional heart failure classification deteriorates, and activation of the neurohumoral axis is unlikely to completely explain the elaboration of pro inflammatory cytokines in heart failure.About:
This article is published in Journal of the American College of Cardiology.The article was published on 1996-04-01 and is currently open access. It has received 1207 citations till now. The article focuses on the topics: Proinflammatory cytokine & Heart failure.read more
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A Novel Paradigm for Heart Failure With Preserved Ejection Fraction: Comorbidities Drive Myocardial Dysfunction and Remodeling Through Coronary Microvascular Endothelial Inflammation
Walter Paulus,Carsten Tschöpe +1 more
TL;DR: In this article, a new paradigm for heart failure with preserved ejection fraction (HFPEF) development is proposed, which identifies a systemic proinflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations.
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Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling
TL;DR: Left ventricular end-diastolic and end-systolic volume and ejection fraction data provide support for the beneficial effects of therapeutic agents such as angiotensin-converting enzyme (ACE) inhibitors and beta-adrenergic blocking agents on the remodeling process.
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Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Tamara B. Harris,Luigi Ferrucci,Russell P. Tracy,M. Chiara Corti,Sholom Wacholder,Walter H. Ettinger,Harley Heimovitz,Harvey J. Cohen,Robert B. Wallace +8 more
TL;DR: In this article, the authors investigated whether interleukin-6 and C-reactive protein levels predict all-cause and cause-specific mortality in a population-based sample of nondisabled older people.
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Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Luigi Ferrucci,Elisa Fabbri +1 more
TL;DR: Whether therapies to modulate inflammageing can reduce the age-related decline in health is discussed, and the hypothesis that inflammation affects CVD, multimorbidity, and frailty is supported by mechanistic studies but requires confirmation in humans.
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Randomized, Double-Blind, Placebo-Controlled, Pilot Trial of Infliximab, a Chimeric Monoclonal Antibody to Tumor Necrosis Factor-α, in Patients With Moderate-to-Severe Heart Failure Results of the Anti-TNF Therapy Against Congestive Heart failure (ATTACH) Trial
TL;DR: Short-term TNF&agr; antagonism with infliximab did not improve and high doses (10 mg/kg) adversely affected the clinical condition of patients with moderate-to-severe chronic heart failure.
References
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Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure.
TL;DR: The addition of enalapril to conventional therapy significantly reduced mortality and hospitalizations for heart failure in patients with chronic congestive heart failure and reduced ejection fractions.
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Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions.
TL;DR: The angiotensin-converting--enzyme inhibitor enalapril significantly reduced the incidence of heart failure and the rate of related hospitalizations, as compared with the rates in the group given placebo, among patients with asymptomatic left ventricular dysfunction.
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Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Jay N. Cohn,T. B. Levine,Maria Teresa Olivari,Garberg,Lura D,Gary S. Francis,Ada B. Simon,Tom S. Rector +7 more
TL;DR: Measurements of Hemodynamics, plasma norepinephrine, and plasma renin activity in patients with moderate to severe congestive heart failure suggest that a single resting venous blood sample showing the plasma norenphrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance.
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Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure
TL;DR: It is indicated that circulating levels of tumor necrosis factor are increased in cachectic patients with chronic heart failure and that this elevation is associated with the marked activation of the renin-angiotensin system seen in patients with end-stage cardiac disease.
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The cardiovascular response of normal humans to the administration of endotoxin
Anthony F. Suffredini,Robert E. Fromm,Margaret M. Parker,Matthew Brenner,Joseph A. Kovacs,Robert Wesley,Joseph E. Parrillo +6 more
TL;DR: It is concluded that the administration of endotoxin to normal subjects causes a depression ofleft ventricular function that is independent of changes in left ventricular volume or vascular resistance, and suggests that endotoxin is a major mediator of the cardiovascular dysfunction in this condition.