C
Claude Trudel
Researcher at Laval University
Publications - 14
Citations - 1022
Claude Trudel is an academic researcher from Laval University. The author has contributed to research in topics: Complementary DNA & Dihydrotestosterone. The author has an hindex of 11, co-authored 14 publications receiving 1001 citations.
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Journal ArticleDOI
Structure and Expression of a New Complementary DNA Encoding the almost Exclusive 3β-Hydroxysteroid Dehydrogenase/Δ5-Δ4-lsomerase in Human Adrenals and Gonads
Eric Rhéaume,Yves Lachance,Hui-Fen Zhao,Nathalie Breton,Marline Dumont,Yvan de Launoit,Claude Trudel,Van Luu-The,Jacques Simard,Fernand Labrie +9 more
TL;DR: A second type of cDNA clone (arbitrarily designated type II) encoding 3βHSD is reported after screening of a human adrenal λgt22A library, which predicts a protein of 371 amino acids with a calculated molecular mass of 41,921 daltons.
Journal ArticleDOI
Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues.
Céline Martel,Eric Rhéaume,Masakazu Takahashi,Claude Trudel,Jacques Couet,Van Luu-The,J. Simard,Fernand Labrie +7 more
TL;DR: The widespread distribution of 17β-HSD in rat and human tissues clearly indicates the importance of this enzyme in peripheral sex steroid formation or intracrinology.
Journal ArticleDOI
Structure and tissue-specific expression of 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase genes in human and rat classical and peripheral steroidogenic tissues.
Fernand Labrie,J. Simard,Van Luu-The,Georges Pelletier,A. Bélanger,Yves Lachance,Hui-Fen Zhao,Claude Labrie,Nathalie Breton,Y. de Launoit,Martine Dumont,Eric Dupont,Eric Rhéaume,Céline Martel,Jacques Couet,Claude Trudel +15 more
TL;DR: It is found that the rat type III mRNA species was below the detection limit in intact female liver while, following hypophysectomy, its accumulation increased to 55% of the levels measured in intact or HYPOX male rats, an increase which can be blocked by administration of ovine prolactin (oPRL).
Journal ArticleDOI
STRUCTURE AND SEXUAL DIMORPHIC EXPRESSION OF A LIVER-SPECIFIC RAT 3β-HYDROXYSTEROID DEHYDROGENASE/ISOMERASE
TL;DR: The present data describe the presence of a third type of 3 beta-HSD mRNA species and its marked sexual dimorphic gene expression in the liver which apparently results from pituitary hormone-induced gene repression in female rat liver tissue.