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Claudia Gottier
Researcher at University of Zurich
Publications - 21
Citations - 609
Claudia Gottier is an academic researcher from University of Zurich. The author has contributed to research in topics: Colitis & Medicine. The author has an hindex of 8, co-authored 18 publications receiving 397 citations.
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Journal ArticleDOI
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
Marianne R. Spalinger,Stephanie Kasper,Claudia Gottier,Silvia Lang,Kirstin Atrott,Stephan R. Vavricka,Sylvie Scharl,Petrus G. M. Gutte,Markus G. Grütter,Hans-Dietmar Beer,Emmanuel Contassot,Andrew C. Chan,Xuezhi Dai,David J. Rawlings,Florian Mair,Burkhard Becher,Werner Falk,Michael Fried,Gerhard Rogler,Michael Scharl +19 more
TL;DR: Tyrosine phosphorylation is identified as an important regulatory mechanism for NLRP3 that prevents aberrant inflammasome activation and subsequent IL-1β release.
Journal ArticleDOI
PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis.
Marianne R. Spalinger,Stephanie Kasper,Christophe Chassard,Tina Raselli,Isabelle Frey-Wagner,Claudia Gottier,Silvia Lang,Kirstin Atrott,Stephan R. Vavricka,Florian Mair,Burkhard Becher,Christophe Lacroix,Michael Fried,Gerhard Rogler,Michael Scharl +14 more
TL;DR: The data demonstrate that dysfunction of PTPN2 results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in human CD, indicating a novel and crucial role for PTPn2 in chronic intestinal inflammation.
Journal ArticleDOI
PTPN22 regulates NLRP3-mediated IL1B secretion in an autophagy-dependent manner
Marianne R. Spalinger,Silvia Lang,Claudia Gottier,Xuezhi Dai,David J. Rawlings,Andrew C. Chan,Gerhard Rogler,Michael Scharl +7 more
TL;DR: This finding shows that autophagy and NLRP3 inflammasome activation are connected, and that PTPN22 plays a key role in the regulation of those 2 pathways.
Journal ArticleDOI
PTPN2 Regulates Inflammasome Activation and Controls Onset of Intestinal Inflammation and Colon Cancer.
Marianne R. Spalinger,Roberto Manzini,Larissa Hering,Julianne B. Riggs,Claudia Gottier,Silvia Lang,Kirstin Atrott,Antonia Fettelschoss,Florian Olomski,Thomas M. Kündig,Michael Fried,Declan F. McCole,Gerhard Rogler,Michael Scharl +13 more
TL;DR: A dual role is identified for myeloid PTPN2 in directly regulating inflammasome activation and IL-1β production to suppress pro-inflammatory responses during colitis but promote intestinal tumor development.
Journal ArticleDOI
Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis.
Sofia Roth,Marianne R. Spalinger,Claudia Gottier,Luc Biedermann,Jonas Zeitz,Silvia Lang,Achim Weber,Gerhard Rogler,Michael Scharl +8 more
TL;DR: A molecular mechanism underlying the anti-inflammatory effects of ARBE treatment in UC patients by modulating T-cell cytokine signalling and inhibiting IFN-γ signal transduction is suggested.