Claudine Scolaro

TL;DR: Results show that these ruthenium(II)-arene complexes can reduce the growth of lung metastases in CBA mice bearing the MCa mammary carcinoma in the absence of a corresponding action at the site of primary tumor growth.

TL;DR: In this article, the authors introduce the organometallic chemist to the fascinating area of organometal pharmaceuticals, and describe the properties of transition metal compounds that lend themselves to medical applications.

TL;DR: The new complexes were found to be highly soluble and kinetically more stable than their RAPTA precursor and showed a similar order of activity in inhibiting cancer cell-growth proliferation and exhibited oligonucleotide binding characteristics similar to those of the RAPT precursor, hence realizing a strategy for developing a new generation of stable and highly water-soluble RAPta adducts.

TL;DR: The most active compound in terms of both Pgp inhibition and cytotoxicity is [Ru(eta6-p-cymene)Cl2(L)], where L is an anthracene-based ligand, and studies show that it induces cell death via inhibition of DNA synthesis.

TL;DR: The reactivity of the functionalized RAPTA compounds with a 14-mer oligonucleotide (established by mass spectrometry) has been rationalized by DFT calculations, which indicate that environmental factors are important.