C
Claudine Scolaro
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 11
Citations - 2089
Claudine Scolaro is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Ruthenium & Cyclopentadienyl complex. The author has an hindex of 10, co-authored 11 publications receiving 1972 citations.
Papers
More filters
Journal ArticleDOI
In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes
Claudine Scolaro,Alberta Bergamo,Laura Brescacin,R. Delfino,Moreno Cocchietto,Gábor Laurenczy,Tilmann J. Geldbach,Gianni Sava,Paul J. Dyson +8 more
TL;DR: Results show that these ruthenium(II)-arene complexes can reduce the growth of lung metastases in CBA mice bearing the MCa mammary carcinoma in the absence of a corresponding action at the site of primary tumor growth.
Journal ArticleDOI
Development of organometallic (organo-transition metal) pharmaceuticals
TL;DR: In this article, the authors introduce the organometallic chemist to the fascinating area of organometal pharmaceuticals, and describe the properties of transition metal compounds that lend themselves to medical applications.
Journal ArticleDOI
Development of Organometallic Ruthenium−Arene Anticancer Drugs That Resist Hydrolysis
Wee Han Ang,Elisa Daldini,Claudine Scolaro,Rosario Scopelliti,Lucienne Juillerat-Jeannerat,Paul J. Dyson +5 more
TL;DR: The new complexes were found to be highly soluble and kinetically more stable than their RAPTA precursor and showed a similar order of activity in inhibiting cancer cell-growth proliferation and exhibited oligonucleotide binding characteristics similar to those of the RAPT precursor, hence realizing a strategy for developing a new generation of stable and highly water-soluble RAPta adducts.
Journal ArticleDOI
Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms.
Carsten A. Vock,Wee Han Ang,Claudine Scolaro,Andrew D. Phillips,Lucienne Lagopoulos,Lucienne Juillerat-Jeanneret,Gianni Sava,Rosario Scopelliti,Paul J. Dyson +8 more
TL;DR: The most active compound in terms of both Pgp inhibition and cytotoxicity is [Ru(eta6-p-cymene)Cl2(L)], where L is an anthracene-based ligand, and studies show that it induces cell death via inhibition of DNA synthesis.
Journal ArticleDOI
Influence of Hydrogen-Bonding Substituents on the Cytotoxicity of RAPTA Compounds
Claudine Scolaro,Tilmann J. Geldbach,Sébastien Rochat,Antoine Dorcier,Christian Gossens,Alberta Bergamo,Moreno Cocchietto,Ivano Tavernelli,Gianni Sava,Ursula Rothlisberger,Paul J. Dyson +10 more
TL;DR: The reactivity of the functionalized RAPTA compounds with a 14-mer oligonucleotide (established by mass spectrometry) has been rationalized by DFT calculations, which indicate that environmental factors are important.