Claudio Maderna

TL;DR: RNA profiling of macrophages and their exosomes shows that miRNA sorting to exosome is modulated by cell-activation-dependent changes of miRNA target levels in the producer cells, and the use of Dicer-deficient cells and reporter lentiviral vectors for miRNA activity shows that exosomal miRNAs are transferred from macrophage to ECs to detectably repress targeted sequences.

TL;DR: In this article , a preclinical model was developed to develop new drugs for treatment of acute hemorrhage in the brain and spinal cord, as an unmet medical emergency for patients with cavernomas.

TL;DR: In this article , an in vivo mimicry platform named SP2G (SPheroid spreading on grids) was developed to identify the most invasive sub-populations of glioblastoma.

TL;DR: Maderna et al. as discussed by the authors described a reliable and cost-effective protocol to evaluate the number and the size of vascular malformations in the murine brain, based on histology and confocal imaging and can be performed with standard laboratory equipment.

TL;DR: Interestingly, in adult mice with an established BBB, the lack of Gpr126 expression in acute ischemic stroke is protective and coupled with reduced microglia activation, which contributes to an improved neurological outcome.