F
Frédéric Burdet
Researcher at Swiss Institute of Bioinformatics
Publications - 24
Citations - 1649
Frédéric Burdet is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Islet & Type 2 diabetes. The author has an hindex of 12, co-authored 22 publications receiving 1234 citations.
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Journal ArticleDOI
Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells
Mario Leonardo Squadrito,Caroline Baer,Frédéric Burdet,Claudio Maderna,Gregor D. Gilfillan,Robert Lyle,Mark Ibberson,Michele De Palma +7 more
TL;DR: RNA profiling of macrophages and their exosomes shows that miRNA sorting to exosome is modulated by cell-activation-dependent changes of miRNA target levels in the producer cells, and the use of Dicer-deficient cells and reporter lentiviral vectors for miRNA activity shows that exosomal miRNAs are transferred from macrophage to ECs to detectably repress targeted sequences.
Journal ArticleDOI
The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans
Pénélope Andreux,William Blanco-Bose,Dongryeol Ryu,Dongryeol Ryu,Frédéric Burdet,Mark Ibberson,Patrick Aebischer,Johan Auwerx,Anurag Singh,Chris Rinsch +9 more
TL;DR: It is shown that UA has a favourable safety profile, and clinical data indicating that urolithin A may improve mitochondrial and cellular health in human muscle is provided, indicating that the compound is well tolerated and bioavailable after oral administration.
Journal ArticleDOI
Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs
Samir Ounzain,Rudi Micheletti,Tal Beckmann,Blanche Schroen,Michael Alexanian,Iole Pezzuto,Stefania Crippa,Mohamed Nemir,Alexandre Sarre,Rory Johnson,Jérôme Dauvillier,Frédéric Burdet,Mark Ibberson,Roderic Guigó,Ioannis Xenarios,Stephane Heymans,Thierry Pedrazzini +16 more
TL;DR: Hundreds of novel heart-specific lncRNAs with unique regulatory and functional characteristics relevant to maladaptive remodelling, cardiac function and possibly cardiac regeneration are revealed.
Journal ArticleDOI
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes
Michele Solimena,Michele Solimena,Anke M. Schulte,Lorella Marselli,Florian Ehehalt,Daniela Richter,Manuela Kleeberg,Hassan Mziaut,Klaus-Peter Knoch,Julia Parnis,Marco Bugliani,Afshan Siddiq,Afshan Siddiq,Anne Jörns,Frédéric Burdet,Robin Liechti,Mara Suleiman,Daniel Margerie,Farooq Syed,Marius Distler,Robert Grützmann,Enrico Petretto,Enrico Petretto,Aida Moreno-Moral,Aida Moreno-Moral,C. Wegbrod,Anke Sönmez,Katja Pfriem,A. Friedrich,Jörn Meinel,Claes B. Wollheim,Gustavo B. Baretton,Raphael Scharfmann,Everson Nogoceke,Ezio Bonifacio,Dorothée Sturm,Birgit Meyer-Puttlitz,Ugo Boggi,Hans-Detlev Saeger,Franco Filipponi,Mathias Lesche,Paolo Meda,Andreas Dahl,Leonore Wigger,Ioannis Xenarios,Mario Falchi,Bernard Thorens,Jürgen Weitz,Krister Bokvist,Sigurd Lenzen,Guy A. Rutter,Philippe Froguel,Manon von Bulow,Mark Ibberson,Piero Marchetti +54 more
TL;DR: These studies enabled the stringent definition of a novel transcriptomic signature of type 2 diabetic islets, regardless of islet source and isolation procedure, which indicates differences possibly due to peculiarities of these hyperglycaemic conditions.
Journal ArticleDOI
Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease
Samir Ounzain,Iole Pezzuto,Rudi Micheletti,Frédéric Burdet,Razan Sheta,Mohamed Nemir,Christine Gonzales,Alexandre Sarre,Michael Alexanian,Matthew J. Blow,Matthew J. Blow,Dalit May,Dalit May,Rory Johnson,Jérôme Dauvillier,Len A. Pennacchio,Len A. Pennacchio,Thierry Pedrazzini +17 more
TL;DR: It is demonstrated that the activity of cardiac enhancers and expression of their target genes are associated with the production of enhancer-derived IncRNAs, including polyadenylated, multi-exonic long noncoding RNAs.