C
Clay Deming
Researcher at National Institutes of Health
Publications - 15
Citations - 3018
Clay Deming is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Microbiome & Candida auris. The author has an hindex of 9, co-authored 15 publications receiving 2247 citations.
Papers
More filters
Journal ArticleDOI
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
Heidi H. Kong,Julia Oh,Clay Deming,Sean Conlan,Elizabeth A. Grice,Melony A. Beatson,Effie Y.H. Nomicos,Eric C. Polley,Hirsh D. Komarow,Nisc Comparative Sequence Program,Patrick R. Murray,Maria L. Turner,Julia A. Segre +12 more
TL;DR: Findings reveal linkages between microbial communities and inflammatory diseases such as AD, and demonstrate that as compared with culture-based studies, higher resolution examination of microbiota associated with human disease provides novel insights into global shifts of bacteria relevant to disease progression and treatment.
Journal ArticleDOI
Biogeography and individuality shape function in the human skin metagenome
Julia Oh,Allyson L. Byrd,Clay Deming,Sean Conlan,Nisc Comparative Sequencing Program,Heidi H. Kong,Julia A. Segre +6 more
TL;DR: This work developed a relational analysis of bacterial, fungal and viral communities, which showed not only site specificity but also individual signatures, and identified strain-level variation of dominant species as heterogeneous and multiphyletic.
Journal ArticleDOI
Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis
Allyson L. Byrd,Allyson L. Byrd,Clay Deming,Sara K. B. Cassidy,Oliver J. Harrison,Weng-Ian Ng,Sean Conlan,Nisc Comparative Sequencing Program,Yasmine Belkaid,Julia A. Segre,Heidi H. Kong +10 more
TL;DR: Results highlight that not all Staphylococcus can be considered the same, even at the strain level, when it comes to atopic dermatitis pathogenesis, and Integrating high-resolution sequencing, culturing, and animal models demonstrated how functional differences of staphylitiscal strains may contribute to the complexity of AD disease.
Journal ArticleDOI
Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance
Rebecca A. Weingarten,Ryan C. Johnson,Sean Conlan,Amanda M. Ramsburg,John P. Dekker,Anna F. Lau,Pavel P. Khil,Robin T. Odom,Clay Deming,Morgan Park,Pamela J. Thomas,Nisc Comparative Sequencing Program,David K. Henderson,Tara N. Palmore,Julia A Segre,Karen M. Frank +15 more
TL;DR: This comprehensive survey revealed a vast, unappreciated reservoir of CPOs in wastewater, which was in contrast to the low positivity rate in both the patient population and the patient-accessible environment, and understanding the plasmid ecology of the hospital environment can assist in the design of control strategies to prevent nosocomial infections.
Journal ArticleDOI
Diverse Human Skin Fungal Communities in Children Converge in Adulthood
Jay-Hyun Jo,Clay Deming,Elizabeth A. Kennedy,Sean Conlan,Eric C. Polley,Weng-Ian Ng,Julia A. Segre,Heidi H. Kong +7 more
TL;DR: Comparisons of fungal communities of primary clinical samples from healthy children and adults indicate that prepubertal skin is colonized by diverse fungi, whereas adult skin is predominantly obligatory lipophilic Malassezia, suggesting thatFungal communities on skin profoundly shift during puberty.