Eric C. Polley

TL;DR: Findings reveal linkages between microbial communities and inflammatory diseases such as AD, and demonstrate that as compared with culture-based studies, higher resolution examination of microbiota associated with human disease provides novel insights into global shifts of bacteria relevant to disease progression and treatment.

TL;DR: This PRS, optimized for prediction of estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset is developed and empirically validated and is a powerful and reliable predictor of breast cancer risk that may improve breast cancer prevention programs.

TL;DR: Several panel genes are established as high- and moderate-risk breast cancer genes and estimates of breast cancer risk associated with pathogenic variants in these genes among individuals qualifying for clinical genetic testing are provided.

TL;DR: To determine whether inherited germline mutations in cancer predisposition genes are associated with increased risks of pancreatic cancer, a case-control study of patients diagnosed as having pancreaticcancer and enrolled in a Mayo Clinic registry between October 12, 2000, and March 31, 2016 was conducted.

TL;DR: In this paper, population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and risk assessment.