Barbara Wegiel

TL;DR: It is indicated that CO transiently induces an anti-Warburg effect by rapidly fueling cancer cell bioenergetics, ultimately resulting in metabolic exhaustion.

TL;DR: The manner in which CO exposure alone modulates the molecular machinery of the cell so that a subsequent stress stimulus will elicit a homeostatic response as opposed to one that is chaotic and disordered is highlighted.

TL;DR: It is demonstrated here that exposure of mφ to CO results in a significant and transient burst of reactive oxygen species (ROS) arising from the mitochondria that promotes rapid activation and stabilization of the transcription factor hypoxia-inducible factor 1α (HIF-1α), which regulates expression of genes involved in inflammation, metabolism, and cell survival.

TL;DR: The A‐type cyclin, cyclin A1 is identified as an important downstream target of PI3K/Akt that transduces survival signals in response to IL6 stimulation and is associated with tumor cell survival in PCa.

TL;DR: It is demonstrated that CO reverses established PAH dependent on NO generation supporting the use of CO clinically to treat pulmonary hypertension.