C
Clémence Thomas
Researcher at French Institute of Health and Medical Research
Publications - 6
Citations - 2577
Clémence Thomas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cancer & Twist transcription factor. The author has an hindex of 5, co-authored 6 publications receiving 2385 citations. Previous affiliations of Clémence Thomas include University of Lyon.
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Journal ArticleDOI
Generation of breast cancer stem cells through epithelial-mesenchymal transition.
Anne-Pierre Morel,Marjory Lièvre,Clémence Thomas,George W. Hinkal,Stéphane Ansieau,Alain Puisieux,Alain Puisieux +6 more
TL;DR: Using a mammary tumor progression model, it is shown that cells possessing both stem and tumorigenic characteristics of “cancer stem cells” can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway.
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Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
Stéphane Ansieau,Jérémy Bastid,Jérémy Bastid,Agnès Doreau,Anne Pierre Morel,Benjamin Pierre Bouchet,Benjamin Pierre Bouchet,Clémence Thomas,Clémence Thomas,Frédérique Fauvet,Isabelle Puisieux,Claudio Doglioni,Sara Piccinin,Roberta Maestro,Thibault Voeltzel,Abdelkader Selmi,Abdelkader Selmi,Sandrine Valsesia-Wittmann,Claude Caron de Fromentel,Alain Puisieux,Alain Puisieux +20 more
TL;DR: It is shown that a large fraction of human cancers overexpress Twist1 and/or Twist2, suggesting an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells.
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EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Anne-Pierre Morel,George W. Hinkal,Clémence Thomas,Frédérique Fauvet,Stéphanie Courtois-Cox,Anne Wierinckx,Mojgan Devouassoux-Shisheboran,Isabelle Treilleux,Agnès Tissier,Baptiste Gras,Julie Pourchet,Isabelle Puisieux,Gareth J. Browne,Douglas B. Spicer,Joël Lachuer,Stéphane Ansieau,Alain Puisieux +16 more
TL;DR: It is shown that down-regulating crucial tumor suppressor functions, EMT inducers make cells particularly prone to malignant conversion, and that cooperation between an EMT inducer and an active form of RAS is sufficient to trigger transformation of mammary epithelial cells into malignant cells.
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IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2
Stéphanie Cochaud,Stéphanie Cochaud,Jérôme Giustiniani,Clémence Thomas,Emilie Laprevotte,Christian Garbar,Aude-Marie Savoye,Hervé Curé,Corinne Mascaux,Gilles Alberici,Nathalie Bonnefoy,Jean-François Eliaou,Armand Bensussan,Armand Bensussan,Jérémy Bastid +14 more
TL;DR: It is demonstrated that a subset of breast tumors is infiltrated with IL-17A-producing cells and recombinant IL- 17A stimulates migration and invasion of breast cancer cells as previously reported and recruits the MAPK pathway by upregulating phosphorylated ERK1/2 in human breast cancer cell lines.
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Early origin of cancer metastases: dissemination and evolution of premalignant cells.
TL;DR: A growing body of evidence supports the idea that metastatic cells disseminate early from the primordial tumor and evolve independently of it, and the interplay between metastatic mechanisms and failsafe mechanism pathways is discussed.