F
Frédérique Fauvet
Researcher at University of Lyon
Publications - 7
Citations - 1090
Frédérique Fauvet is an academic researcher from University of Lyon. The author has contributed to research in topics: Epithelial–mesenchymal transition & Cancer cell. The author has an hindex of 5, co-authored 6 publications receiving 966 citations. Previous affiliations of Frédérique Fauvet include Claude Bernard University Lyon 1.
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Journal ArticleDOI
Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
Stéphane Ansieau,Jérémy Bastid,Jérémy Bastid,Agnès Doreau,Anne Pierre Morel,Benjamin Pierre Bouchet,Benjamin Pierre Bouchet,Clémence Thomas,Clémence Thomas,Frédérique Fauvet,Isabelle Puisieux,Claudio Doglioni,Sara Piccinin,Roberta Maestro,Thibault Voeltzel,Abdelkader Selmi,Abdelkader Selmi,Sandrine Valsesia-Wittmann,Claude Caron de Fromentel,Alain Puisieux,Alain Puisieux +20 more
TL;DR: It is shown that a large fraction of human cancers overexpress Twist1 and/or Twist2, suggesting an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells.
Journal ArticleDOI
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Anne-Pierre Morel,George W. Hinkal,Clémence Thomas,Frédérique Fauvet,Stéphanie Courtois-Cox,Anne Wierinckx,Mojgan Devouassoux-Shisheboran,Isabelle Treilleux,Agnès Tissier,Baptiste Gras,Julie Pourchet,Isabelle Puisieux,Gareth J. Browne,Douglas B. Spicer,Joël Lachuer,Stéphane Ansieau,Alain Puisieux +16 more
TL;DR: It is shown that down-regulating crucial tumor suppressor functions, EMT inducers make cells particularly prone to malignant conversion, and that cooperation between an EMT inducer and an active form of RAS is sufficient to trigger transformation of mammary epithelial cells into malignant cells.
Journal ArticleDOI
A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.
Anne-Pierre Morel,Anne-Pierre Morel,Christophe Ginestier,Roxane M. Pommier,Roxane M. Pommier,Olivier Cabaud,Emmanuelle Ruiz,Emmanuelle Ruiz,Julien Wicinski,Mojgan Devouassoux-Shisheboran,Mojgan Devouassoux-Shisheboran,Valérie Combaret,Pascal Finetti,Christelle Chassot,Christelle Chassot,Christiane Pinatel,Christiane Pinatel,Frédérique Fauvet,Frédérique Fauvet,Pierre Saintigny,Pierre Saintigny,Emilie Thomas,Caroline Moyret-Lalle,Caroline Moyret-Lalle,Joël Lachuer,Joël Lachuer,Emmanuelle Despras,Jean-Luc Jauffret,François Bertucci,Jérôme Guitton,Anne Wierinckx,Anne Wierinckx,Qing Wang,Nina Radosevic-Robin,Frédérique Penault-Llorca,David G. Cox,David G. Cox,Frédéric Hollande,Stéphane Ansieau,Stéphane Ansieau,Julie Caramel,Julie Caramel,Daniel Birnbaum,Arnaud M. Vigneron,Arnaud M. Vigneron,Agnès Tissier,Agnès Tissier,Emmanuelle Charafe-Jauffret,Alain Puisieux,Alain Puisieux +49 more
TL;DR: It is shown that the differentiation status of normal human mammary epithelial cells dictates cell behavior after an oncogenic event and predetermines the genetic routes toward malignancy, thereby increasing stem cells' intrinsic susceptibility to malignant transformation.
Journal ArticleDOI
Snail family members unequally trigger EMT and thereby differ in their ability to promote the neoplastic transformation of mammary epithelial cells.
Baptiste Gras,Laurent Jacqueroud,Anne Wierinckx,Christelle Lamblot,Frédérique Fauvet,Joël Lachuer,Alain Puisieux,Stéphane Ansieau +7 more
TL;DR: It is demonstrated that when a SNAIL protein is ectopically produced in non-transformed mammary epithelial cells, the cells are protected from anoikis and proliferate under low-adherence conditions: a hallmark of cancer cells.
Journal ArticleDOI
EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers
Mélanie K. Prodhomme,Mélanie K. Prodhomme,Roxane M. Pommier,Roxane M. Pommier,Camille Franchet,Frédérique Fauvet,Frédérique Fauvet,Valérie Bergoglio,Pierre Brousset,Anne-Pierre Morel,Anne-Pierre Morel,Anne-Cécile Brunac,Mojgan Devouassoux-Shisheboran,Mojgan Devouassoux-Shisheboran,Virginie Petrilli,Caroline Moyret-Lalle,Caroline Moyret-Lalle,Jean-Sébastien Hoffmann,Alain Puisieux,Alain Puisieux,Alain Puisieux,Agnès Tissier,Agnès Tissier +22 more
TL;DR: It is shown that ZEB1 directly inhibits the expression of POLQ and, therefore, TMEJ activity, controlling both stability and integrity of breast cancer cell genomes.