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Anne Wierinckx
Researcher at University of Lyon
Publications - 29
Citations - 2080
Anne Wierinckx is an academic researcher from University of Lyon. The author has contributed to research in topics: Pituitary tumors & Pituitary adenoma. The author has an hindex of 21, co-authored 26 publications receiving 1804 citations. Previous affiliations of Anne Wierinckx include VU University Medical Center & Claude Bernard University Lyon 1.
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A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma.
Julie Caramel,Eftychios Papadogeorgakis,Louise Hill,Gareth J. Browne,Geoffrey Richard,Anne Wierinckx,Gerald Saldanha,J.E. Osborne,Peter E. Hutchinson,Gina Tse,Joël Lachuer,Alain Puisieux,J. Howard Pringle,Stéphane Ansieau,Eugene Tulchinsky +14 more
TL;DR: It is found that regulation and functions of EMT-TFs are different in malignant melanoma and this switch results in E-cadherin loss, enhanced invasion, and constitutes an independent factor of poor prognosis in melanoma patients.
Journal ArticleDOI
From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal
Sylvia L. Asa,Olivera Casar-Borota,Philippe Chanson,Etienne Delgrange,P Earls,Shereen Ezzat,Ashley B. Grossman,H Ikeda,Naoko Inoshita,Niki Karavitaki,Márta Korbonits,Edward R. Laws,M. B. S. Lopes,Nicholas F. Maartens,Ian E. McCutcheon,Ozgur Mete,Hiroshi Nishioka,Gérald Raverot,Federico Roncaroli,Wolfgang Saeger,Luis V. Syro,Alexandre Vasiljevic,Chiara Villa,Anne Wierinckx,Jacqueline Trouillas +24 more
TL;DR: A new terminology, pituitary neuroendocrine tumor (PitNET), is proposed, which is consistent with that used for other neuro endocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.
Journal ArticleDOI
EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Anne-Pierre Morel,George W. Hinkal,Clémence Thomas,Frédérique Fauvet,Stéphanie Courtois-Cox,Anne Wierinckx,Mojgan Devouassoux-Shisheboran,Isabelle Treilleux,Agnès Tissier,Baptiste Gras,Julie Pourchet,Isabelle Puisieux,Gareth J. Browne,Douglas B. Spicer,Joël Lachuer,Stéphane Ansieau,Alain Puisieux +16 more
TL;DR: It is shown that down-regulating crucial tumor suppressor functions, EMT inducers make cells particularly prone to malignant conversion, and that cooperation between an EMT inducer and an active form of RAS is sufficient to trigger transformation of mammary epithelial cells into malignant cells.
Journal ArticleDOI
Interferon-β directly influences monocyte infiltration into the central nervous system
Sarah Floris,S.R. Ruuls,Anne Wierinckx,Susanne M. A. van der Pol,Ed A. Döpp,Peter H. van der Meide,Christine D. Dijkstra,Helga E. de Vries +7 more
TL;DR: It is suggested that IFN-beta directly modulates inflammatory events at the level of cerebral endothelium, thereby contributing to reduced lesion formation as observed in MS patients.
Journal ArticleDOI
A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability.
Anne-Pierre Morel,Anne-Pierre Morel,Christophe Ginestier,Roxane M. Pommier,Roxane M. Pommier,Olivier Cabaud,Emmanuelle Ruiz,Emmanuelle Ruiz,Julien Wicinski,Mojgan Devouassoux-Shisheboran,Mojgan Devouassoux-Shisheboran,Valérie Combaret,Pascal Finetti,Christelle Chassot,Christelle Chassot,Christiane Pinatel,Christiane Pinatel,Frédérique Fauvet,Frédérique Fauvet,Pierre Saintigny,Pierre Saintigny,Emilie Thomas,Caroline Moyret-Lalle,Caroline Moyret-Lalle,Joël Lachuer,Joël Lachuer,Emmanuelle Despras,Jean-Luc Jauffret,François Bertucci,Jérôme Guitton,Anne Wierinckx,Anne Wierinckx,Qing Wang,Nina Radosevic-Robin,Frédérique Penault-Llorca,David G. Cox,David G. Cox,Frédéric Hollande,Stéphane Ansieau,Stéphane Ansieau,Julie Caramel,Julie Caramel,Daniel Birnbaum,Arnaud M. Vigneron,Arnaud M. Vigneron,Agnès Tissier,Agnès Tissier,Emmanuelle Charafe-Jauffret,Alain Puisieux,Alain Puisieux +49 more
TL;DR: It is shown that the differentiation status of normal human mammary epithelial cells dictates cell behavior after an oncogenic event and predetermines the genetic routes toward malignancy, thereby increasing stem cells' intrinsic susceptibility to malignant transformation.