Cliff Pereira

TL;DR: Mild acute stresses applied to rainbow trout females may affect certain reproductive performance parameters such as timing of ovulation and relative fecundity; however, the progeny of such stressed females perform as well as controls with regard to juvenile growth and disease resistance.

TL;DR: Results are consistent with the hypothesis that two major factors determining the carcinogenic activity of PAH within a complex mixture are the persistence of certain PAH-DNA adducts as well as total adduct levels and the ability of the components present in the mixture to inhibit the activation of carcinogenic PAH by the induced CYP enzymes.

TL;DR: Chlorophyllin (CHL), a food-grade derivative of the ubiquitous green plant pigment chlorophyll, is a potent, dose-responsive inhibitor of aflatoxin B1 DNA adduction and hepatocarcinogenesis in the rainbow trout model when fed with carcinogen.

TL;DR: The polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), was compared to dibenzo[def,p]chrysene (DBC) and combinations of three environmental PAH mixtures using a two stage, FVB/N mouse skin tumor model and the carcinogenicity with DBC and two of the mixtures was much greater than would be predicted based on published Relative Potency Factors (RPFs).

TL;DR: Data demonstrate that gross induction of the MFO system was not necessarily required for alterations in DNA adduct formation in vivo or protection against AFB1 carcinogenesis, while the other compounds were less effective.