C
Clifford Yen
Researcher at Cold Spring Harbor Laboratory
Publications - 3
Citations - 5180
Clifford Yen is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Copy-number variation & Cancer. The author has an hindex of 2, co-authored 3 publications receiving 4981 citations.
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Journal ArticleDOI
PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
Jing Li,Clifford Yen,Danny Liaw,Katrina Podsypanina,Shikha Bose,Steven I. Wang,Janusz Puc,Christa Miliaresis,Linda Rodgers,Richard W. McCombie,Sandra H. Bigner,Beppino C. Giovanella,Michael Ittmann,B. Tycko,Hanina Hibshoosh,Michael Wigler,Ramon Parsons +16 more
TL;DR: The PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions as discussed by the authors.
Journal ArticleDOI
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene
David Mu,Liyun Chen,Xi-Ping Zhang,Lei-Hoon See,Christina M Koch,Clifford Yen,James Jiayuan Tong,Lori Spiegel,Ken C. Q. Nguyen,Allyson Servoss,Yue Peng,Lin Pei,Jeffrey R. Marks,Scott W. Lowe,Timothy Hoey,Lily Yeh Jan,W. Richard McCombie,Michael Wigler,Scott Powers +18 more
TL;DR: Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation, suggesting that its amplification and overexpression plays a physiologically important role in human breast cancer.
Journal ArticleDOI
Application of representational microarrays to genetic analysis of primary tumours
Robert Lucito,Joe West,Andy Reiner,Joan Alexander,Clifford Yen,Mariko Nakamura,Michael Wigler +6 more
TL;DR: DNA microarrays for measuring gene copy number in cancer biopsies are explored, combining copy-number analysis with expression analysis for the same tumours, enabling the user to more readily identify the primary defects in cancer cells.